ChemicalBook > CAS DataBase List > Spastazoline

Spastazoline

Product Name: Spastazoline
CAS No.: 2351882-11-4
Chemical Name: Spastazoline
Synonyms: Spastazoline;Spastazoline, 10 mM in DMSO;(R)-N-(5-(tert-Butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;HeLa,microtubule-severing,Inhibitor,inhibit,division,vesicle transport,Spastazoline,cell division,AAA protein,selective;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[5-(1,1-dimethylethyl)-1H-pyrazol-3-yl]-2-[(3R)-3-(1-methylethyl)-1-piperazinyl]-
CBNumber: CB74918009
Molecular Formula: C20H30N8
Formula Weight: 382.51
MOL File: 2351882-11-4.mol

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Spastazoline Property

Density: 1.222±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (261.43 mM; Need ultrasonic)
form: Solid
pka: 14.26±0.50(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611938
Product name: Spastazoline
Purity: >98%
Packaging: 100mg
Price: $1133.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611938
Product name: Spastazoline
Purity: >98%
Packaging: 250mg
Price: $1949.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611938
Product name: Spastazoline
Purity: >98%
Packaging: 1g
Price: $3876
Updated: 2021/12/16

DC Chemicals

Product number: DC26007
Product name: Spastazoline
Purity: >98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC26007
Product name: Spastazoline
Purity: >98%
Packaging: 1g
Price: $2600
Updated: 2021/12/16

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Spastazoline Chemical Properties,Usage,Production

Uses

Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research[1].

Biological Activity

Spastazoline is a cell penetrant, potent and selective ATP-competitive inhibitor of spastin.

References

[1] Cupido T, et al. Designing a chemical inhibitor for the AAA protein spastin using active site mutations. Nat Chem Biol. 2019 Feb 18. DOI:10.1038/s41589-019-0225-6

Spastazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2351882-11-4, SpastazolineRelated Search:

Spastazoline

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[5-(1,1-dimethylethyl)-1H-pyrazol-3-yl]-2-[(3R)-3-(1-methylethyl)-1-piperazinyl]-

(R)-N-(5-(tert-Butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HeLa,microtubule-severing,Inhibitor,inhibit,division,vesicle transport,Spastazoline,cell division,AAA protein,selective

Spastazoline, 10 mM in DMSO

2351882-11-4