IMGN-779

Product Name: IMGN-779
CAS No.: 1394079-41-4
Chemical Name: IMGN-779
Synonyms: DGN-462;IMGN-779;IMGN779-Linker;6H-Indolo[2,1-c][1,4]benzodiazepin-6-one, 9-[[3-[[[(12aS)-12a,13-dihydro-8-methoxy-6-oxo-6H-indolo[2,1-c][1,4]benzodiazepin-9-yl]oxy]methyl]-5-[(2-mercapto-2-methylpropyl)[2-[2-(2-methoxyethoxy)ethoxy]ethyl]amino]phenyl]methoxy]-11,12,12a,13-tetrahydro-8-methoxy-, (12aS)-
CBNumber: CB74918276
Molecular Formula: C53H59N5O9S
Formula Weight: 942.13
MOL File: 1394079-41-4.mol

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IMGN-779 Property

Density: 1.31±0.1 g/cm3(Predicted)
pka: 10.88±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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IMGN-779 Chemical Properties,Usage,Production

Uses

DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1].

References

[1] Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639. DOI:10.3324/haematol.2018.211011

IMGN-779 Preparation Products And Raw materials

Raw materials

Preparation Products

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IMGN-779 Suppliers

China 4 United States 1 Global 5

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

1394079-41-4, IMGN-779Related Search:

DGN-462

IMGN-779

IMGN779-Linker

6H-Indolo[2,1-c][1,4]benzodiazepin-6-one, 9-[[3-[[[(12aS)-12a,13-dihydro-8-methoxy-6-oxo-6H-indolo[2,1-c][1,4]benzodiazepin-9-yl]oxy]methyl]-5-[(2-mercapto-2-methylpropyl)[2-[2-(2-methoxyethoxy)ethoxy]ethyl]amino]phenyl]methoxy]-11,12,12a,13-tetrahydro-8-methoxy-, (12aS)-

1394079-41-4