MC-310911

Product Name: MC-310911
CAS No.: 1000287-05-7
Chemical Name: MC-310911
Synonyms: ASC-09;MC-310911;TMC-310911;TMC310911,TMC-310911;(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((2-((1-cyclopentylpiperidin-4-yl)amino)-N-isobutylbenzo[d]thiazole)-6-sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate;(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)-2-[(1-cyclopentylpiperidin-4-yl)amino]-1,3-benzothiazole-6-sulfonamido]-1-phenylbutan-2-yl]carbamate;Carbamic acid, N-[(1S,2R)-3-[[[2-[(1-cyclopentyl-4-piperidinyl)amino]-6-benzothiazolyl]sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
CBNumber: CB74918281
Molecular Formula: C38H53N5O7S2
Formula Weight: 755.99
MOL File: 1000287-05-7.mol

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MC-310911 Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (132.28 mM; Need ultrasonic)
form: Solid
pka: 11.40±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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MC-310911 Chemical Properties,Usage,Production

Uses

TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity[1][2].

References

[1] Dierynck I, et al. TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors. Antimicrob Agents Chemother. 2011 Dec;55(12):5723-31. DOI:10.1128/AAC.00748-11
[2] Stellbrink HJ, et al. Antiviral activity, pharmacokinetics, and safety of the HIV-1 protease inhibitor TMC310911, coadministered with ritonavir, in treatment-naive HIV-1-infected patients. J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):283-9. DOI:10.1097/QAI.0000000000000003

MC-310911 Preparation Products And Raw materials

Raw materials

Preparation Products

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MC-310911 Suppliers

China 9 United States 3 Global 12

Kaixin Chemical (Hong Kong) Limited

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Alfa Chemistry

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Block Chemical Technology (Shanghai) Co., Ltd.

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Block Chemical Technology (Shanghai) Co., Ltd.

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TargetMol Chemicals Inc.

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RD International Technology Co., Limited

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Biosynth Biological Technology (Suzhou) Co Ltd

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TargetMol Chemicals Inc.

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1000287-05-7, MC-310911Related Search:

ASC-09

MC-310911

Carbamic acid, N-[(1S,2R)-3-[[[2-[(1-cyclopentyl-4-piperidinyl)amino]-6-benzothiazolyl]sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((2-((1-cyclopentylpiperidin-4-yl)amino)-N-isobutylbenzo[d]thiazole)-6-sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate

TMC-310911

(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S,3R)-3-hydroxy-4-[N-(2-methylpropyl)-2-[(1-cyclopentylpiperidin-4-yl)amino]-1,3-benzothiazole-6-sulfonamido]-1-phenylbutan-2-yl]carbamate

TMC310911,TMC-310911

1000287-05-7

C38H53N5O7S2