ChemicalBook > CAS DataBase List > SW-100

SW-100

Product Name: SW-100
CAS No.: 2126744-35-0
Chemical Name: SW-100
Synonyms: SW-100;SW-100, 10 mM in DMSO;HDAC,SW-100,Histone deacetylases,Inhibitor,SW 100,inhibit,SW100;4-[(6-chloro-3,4-dihydro-2H-quinolin-1-yl)methyl]-N-hydroxybenzamide;4-((6-CHLORO-3,4-DIHYDROQUINOLIN-1(2H)-YL)METHYL)-N-HYDROXYBENZAMIDE;4-[(6-chloro-1,2,3,4-tetrahydroquinolin-1-yl)methyl]-N-hydroxybenzamide;Benzamide, 4-[(6-chloro-3,4-dihydro-1(2H)-quinolinyl)methyl]-N-hydroxy-
CBNumber: CB74918296
Molecular Formula: C17H17ClN2O2
Formula Weight: 316.78
MOL File: 2126744-35-0.mol

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SW-100 Property

storage temp.: Store at -20°C
solubility: DMSO : ≥ 125 mg/mL (394.60 mM)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087024
Product name: SW-100
Purity: 99.92%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0087024
Product name: SW-100
Purity: 99.92%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009821
Product name: SW-100
Purity: 95.00%
Packaging: 5MG
Price: $453.51
Updated: 2021/12/16

ChemScene

Product number: CS-0087024
Product name: SW-100
Purity: 99.92%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0087024
Product name: SW-100
Purity: 99.92%
Packaging: 100mg
Price: $1500
Updated: 2021/12/16

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SW-100 Chemical Properties,Usage,Production

Uses

SW-100 HDAC6 Inhibitor is used in methods of treating PACS1 and PACS2 syndromes comprising administering an HDAC6 or SIRT2 inhibitor in relation to restoring Golgi morphology in a cell.

in vivo

SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in mouse model of Fragile X syndrome^[1].

Animal Model:	8-10 weeks old C57BL/6 mice (Fmr1^-/- mice)^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; twice a day for two days
Result:	Ameliorated several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing in Fmr1^-/-mice。

IC 50

HDAC1: 5.23 μM (IC₅₀); HDAC2: 32.8 μM (IC₅₀); HDAC3: 29.5 μM (IC₅₀); HDAC4: 10.9 μM (IC₅₀); HDAC5: 4.07 μM (IC₅₀); HDAC6: 2.3 nM (IC₅₀); HDAC7: 4.55 μM (IC₅₀); HDAC8: 3.72 μM (IC₅₀); HDAC9: 3.46 μM (IC₅₀); HDAC10: 26.2 μM (IC₅₀); HDAC11: 5.72 μM (IC₅₀)

SW-100 Preparation Products And Raw materials

Raw materials

Preparation Products

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SW-100 Suppliers

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2126744-35-0, SW-100Related Search:

SW-100

Benzamide, 4-[(6-chloro-3,4-dihydro-1(2H)-quinolinyl)methyl]-N-hydroxy-

4-((6-CHLORO-3,4-DIHYDROQUINOLIN-1(2H)-YL)METHYL)-N-HYDROXYBENZAMIDE

HDAC,SW-100,Histone deacetylases,Inhibitor,SW 100,inhibit,SW100

4-[(6-chloro-1,2,3,4-tetrahydroquinolin-1-yl)methyl]-N-hydroxybenzamide

SW-100, 10 mM in DMSO

4-[(6-chloro-3,4-dihydro-2H-quinolin-1-yl)methyl]-N-hydroxybenzamide

2126744-35-0