CHLORISONDAMINE DIIODIDE

Product Name: CHLORISONDAMINE DIIODIDE
CAS No.: 96750-66-2
Chemical Name: CHLORISONDAMINE DIIODIDE
Synonyms: Chlorisondamine (iodide);CHLORCHLORISONDAMINE DIIODIDEISONDAMINE DIIODIDE;4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide
CBNumber: CB7497364
Molecular Formula: C14Cl4H20I2N2
Formula Weight: 611.94
MOL File: 96750-66-2.mol

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CHLORISONDAMINE DIIODIDE Property

storage temp.: 2-8°C
solubility: H₂O: ~3.75 mg/mL
form: solid
color: white
Water Solubility: Soluble to 10 mM in water

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5366
Product name: Chlorisondamine diiodide
Purity: ≥98% (HPLC), white solid
Packaging: 10mg
Price: $195
Updated: 2025/07/31

Sigma-Aldrich

Product number: C5366
Product name: Chlorisondamine diiodide
Purity: ≥98% (HPLC), white solid
Packaging: 50mg
Price: $734
Updated: 2025/07/31

Cayman Chemical

Product number: 20119
Product name: Chlorisondamine (iodide)
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 20119
Product name: Chlorisondamine (iodide)
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 20119
Product name: Chlorisondamine (iodide)
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

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CHLORISONDAMINE DIIODIDE Chemical Properties,Usage,Production

Description

Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC₅₀ = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 | 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg.

Uses

Chlorisondamine diiodide has been used:

as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

Biochem/physiol Actions

Chlorisondamine diiodide mediates ganglionic and central blockade.

in vivo

Chlorisondamine (0.2, 1.0, 5.0 μg; IV; single dosage) antagonizes the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks^[1].

Animal Model:	Rats (treated once with nicotine 0.4 mg/kg, s.c.)^[1]
Dosage:	0.2, 1.0, 5.0 μg
Administration:	IV; single dosage
Result:	Antagonized the depressant action of nicotine on vertical activity (0-20min) in a dose-dependent way at 1 and 2 weeks.

References

[1] H. EL-BIZRI P. B S C. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro[J]. British Journal of Pharmacology, 1994, 111 2: 406-413. DOI: 10.1111/j.1476-5381.1994.tb14749.x
[2] CLARKE P B. Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine.[J]. British Journal of Pharmacology, 1984, 83 2: 527-535. DOI: 10.1111/j.1476-5381.1984.tb16517.x
[3] C. REAVILL. Chlorisondamine blocks acquisition of the conditioned taste aversion produced by (?)-nicotine[J]. Neuropharmacology, 1986, 25 9: Pages 1067-1069. DOI: 10.1016/0028-3908(86)90204-2
[4] A J PLUMMER. Ganglionic blockade by a new bisquaternary series, including chlorisondamine dimethochloride.[J]. Journal of Pharmacology and Experimental Therapeutics, 1955, 115 2: 172-184.

CHLORISONDAMINE DIIODIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CHLORISONDAMINE DIIODIDE Suppliers

China 18 Switzerland 1 United Kingdom 1 United States 6 Global 26

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96750-66-2, CHLORISONDAMINE DIIODIDERelated Search:

4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide

Chlorisondamine (iodide)

CHLORCHLORISONDAMINE DIIODIDEISONDAMINE DIIODIDE

96750-66-2

C14H20Cl4N22I