ETHCHLORVYNOL CIV (0.7 ML) Property

Melting point:

25°C

Boiling point:

bp760 173-174°; also reported as bp760 181°; bp0.1 28.5-30°

Density 

d425 1.065-1.070; also reported as d420 1.070

refractive index 

nD25 1.4675-1.4800

solubility 

Chloroform (Soluble), Methanol (Slightly)

form 

Oil

pka

12.06±0.29(Predicted)

color 

Colourless

Safety

HS Code 

2905510000

Hazardous Substances Data

113-18-8(Hazardous Substances Data)

Toxicity

LD50 in mice (mg/kg): 290 orally; 240 s.c. (P'an)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

ETHCHLORVYNOL CIV (0.7 ML) Chemical Properties,Usage,Production

Chemical Properties

Clear Colorless Oil

Originator

Placidyl,Abbott,US,1965

Uses

Controlled substance (depressant). Sedative; hypnotic.

Definition

ChEBI: Propargyl alcohol in which the methylene hydrogens are substituted by ethyl and 2-chlorovinyl groups. A hypnotic and sedative, it is used for treatment of insomnia in some cases where an intolerance or allergy to more commonly used drugs exists.

Manufacturing Process

Acetylene was passed into a stirred solution of 3.05 grams (0.44 mol) of lithium in 300 ml of liquid ammonia until the blue color exhibited by the mixture had disappeared. Ethyl β-chlorovinyl ketone (47.4 grams; 0.40 mol) dissolved in 50 ml dry ether was then added to the resulting solution of lithium acetylide over a period of 20 minutes, during which the color deepened through yellow to reddish-brown. The mixture was stirred under reflux maintained with a Dry Ice condenser for 2 hours. Thereafter, dry ether (200 ml) was added and the ammonia was permitted to evaporate with stirring overnight.
The residue was poured into a slurry of ice and water containing 30 grams (0.50 mol) of acetic acid. After separating the ether layer, the aqueous layer was washed with two 200 milliliter portions of ether. The combined ether extracts were washed with saturated sodium bicarbonate solution, dried over anhydrous magnesium sulfate and evaporated in a stream of pure nitrogen. Three successive distillations of the residue gave 46.3 grams (80.2% yield) of a colorless liquid, boiling point 28.5° to 30°C at 0.1 mm Hg.

brand name

Placidyl (Abbott).

Therapeutic Function

Sedative, Hypnotic

Safety Profile

Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: general anesthesia and thrombocytopenia (reduction in the number of blood platelets). Human effects on newborn by an unspecified route: drug dependency and Apgar score (condtion of newborn). Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Cl-.