RAC 8-HYDROXY EFAVIRENZ

Product Name: RAC 8-HYDROXY EFAVIRENZ
CAS No.: 205754-33-2
Chemical Name: RAC 8-HYDROXY EFAVIRENZ
Synonyms: 8-HydroxyEfavirenz;RAC 8-HYDROXY EFAVIRENZ;Efavirenz Impurity 11(8-Hydroxy Efavirenz);(4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one;6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-;8-Hydroxy EfavirenzQ: What is 8-Hydroxy Efavirenz Q: What is the CAS Number of 8-Hydroxy Efavirenz Q: What is the storage condition of 8-Hydroxy Efavirenz Q: What are the applications of 8-Hydroxy Efavirenz
CBNumber: CB7501021
Molecular Formula: C14H9ClF3NO3
Formula Weight: 331.67
MOL File: 205754-33-2.mol

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RAC 8-HYDROXY EFAVIRENZ Property

Melting point:: 144-154°C
Boiling point:: 373.6±42.0 °C(Predicted)
Density: 1?+-.0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Acetonitrile: soluble; DMSO: soluble; Methanol: soluble
form: A solid
pka: 7.18±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27853
Product name: 8-hydroxy Efavirenz
Packaging: 1mg
Price: $605
Updated: 2024/03/01

Usbiological

Product number: H9044-30
Product name: rac 8-Hydroxy Efavirenz
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: H941830
Product name: 8-HydroxyEfavirenz(~90%)
Packaging: 2.5mg
Price: $6595
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010043
Product name: 8-HYDROXYEFAVIRENZ
Purity: 95.00%
Packaging: 1MG
Price: $446.25
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010043
Product name: 8-HYDROXYEFAVIRENZ
Purity: 95.00%
Packaging: 5MG
Price: $504.72
Updated: 2021/12/16

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RAC 8-HYDROXY EFAVIRENZ Chemical Properties,Usage,Production

Description

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.

Chemical Properties

Off-White Solid

Uses

A labellebed metabolite of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor

Uses

8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.

RAC 8-HYDROXY EFAVIRENZ Preparation Products And Raw materials

Raw materials

Preparation Products

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RAC 8-HYDROXY EFAVIRENZ Suppliers

Canada 1 China 21 Germany 1 India 3 United States 5 Global 31

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205754-33-2, RAC 8-HYDROXY EFAVIRENZRelated Search:

SE 563 Efavirenz AMino Alcohol Ethyl CarbaMate rac Methyl Efavirenz Efavirenz Related Compound B (15 mg) ((S,E)-6-Chloro-4-(2-Cyclopropylvinyl)-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one) rac 8-Hydroxy Efavirenz Efavirenz Related Compound C (20 mg) (6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinoline) 6-chloro-4-pent-1-ynyl-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one L 741211 Efavirenz rac 8,14-Dihydroxy Efavirenz (S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-2-(4-methoxyphenyl)-4-(trifluoromethyl)-2H-3,1-benzoxazine(Mixture of 2 Diastereomers) Efavirenz IP Impurity A rac 7-Hydroxy Efavirenz [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester (S)-5-chloro-a-(Cyclopropylacetenyl)-2-[((4-methoxyphenyl)methyl)amino]-a- (trifluoromethyl) benzenemethanol (E-4) Enantiomer Efavirenz Efavirenz Impurity 13(7-Hydroxy Efavirenz)

RAC 8-HYDROXY EFAVIRENZ

8-HydroxyEfavirenz

6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

(4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one

Efavirenz Impurity 11(8-Hydroxy Efavirenz)

2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-

8-Hydroxy EfavirenzQ: What is 8-Hydroxy Efavirenz Q: What is the CAS Number of 8-Hydroxy Efavirenz Q: What is the storage condition of 8-Hydroxy Efavirenz Q: What are the applications of 8-Hydroxy Efavirenz

2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-

205754-33-2

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Metabolites

Non-nucleoside Reverse Transcriptase

Pharmaceuticals