ChemicalBook > CAS DataBase List > 2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID

2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID

Product Name
2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID
CAS No.
406482-20-0
Chemical Name
2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID
Synonyms
Difluoro-4-Methoxyphenylboronic;26-Difluoro-4-MethoxyphenylboronicAci;6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID;2,6-Difluoro-4-methoxybenzeneboronic acid;Boronic acid, (2,6-difluoro-4-methoxyphenyl)-;2,6-Difluoro-4-Methoxyphenylboronic acid >=95%;Boronic acid, B-(2,6-difluoro-4-methoxyphenyl)-;2,6-Difluoro-4-methoxyphenylboronicAcid(containsvaryingamountsofAnhydride)>2,6-Difluoro-4-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
CBNumber
CB7505195
Molecular Formula
C7H7BF2O3
Formula Weight
187.94
MOL File
406482-20-0.mol
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2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID Property

Melting point:
125-130 °C(lit.)
Boiling point:
269.3±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
8.55±0.58(Predicted)
color 
White to Almost white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
593060
Product name
2,6-Difluoro-4-methoxyphenylboronic acid
Purity
≥95%
Packaging
1g
Price
$67
Updated
2023/06/20
Sigma-Aldrich
Product number
593060
Product name
2,6-Difluoro-4-methoxyphenylboronic acid
Purity
≥95%
Packaging
5g
Price
$175
Updated
2023/06/20
TCI Chemical
Product number
D4728
Product name
2,6-Difluoro-4-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$76
Updated
2025/07/31
TRC
Product number
D448278
Product name
2,6-Difluoro-4-methoxyphenylboronic acid
Packaging
500mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
6660-3-T5
Product name
2,6-Difluoro-4-methoxybenzeneboronic acid
Packaging
1g
Price
$40
Updated
2021/12/16
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2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID Chemical Properties,Usage,Production

Uses

suzuki reaction

Uses

2,6-Difluoro-4-methoxyphenylboronic acid can be used:

  • To prepare a ligand N4Py2Ar2, which in turn is used to synthesize a Fe complex, employed in aromatic C?F hydroxylation reactions.
  • As a substrate in the study of copper-catalyzed trifluoromethylthiolation of boronic acids.
  • As a substrate in the preparation of a thio xylopyranoside as a potent antithrombotic agent.

Synthesis

890839-37-9

406482-20-0

General procedure for the synthesis of 2,6-difluoro-4-methoxyphenylboronic acid from 2-(3,5-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) anisole: To an acetone solution of 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) anisole (0.88 g. 15 mL) was added to an aqueous ammonium acetate solution (18 mL, 1 mol/L aqueous solution) and sodium metaiodate (2.6 g). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the mixture was concentrated, diluted with water and extracted with ethyl acetate. The organic phases were combined, dried with sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent cyclohexane/ethyl acetate (1:0→1:1). The target product 2,6-difluoro-4-methoxyphenylboronic acid was obtained in a yield of 0.27 g in 44%.

References

[1] Patent: WO2008/34859, 2008, A1. Location in patent: Page/Page column 40

2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID Suppliers

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View Lastest Price from 2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID manufacturers

Career Henan Chemical Co
Product
2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID 406482-20-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%-100%
Supply Ability
1
Release date
2018-08-12

406482-20-0, 2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACIDRelated Search:

4-Methoxyphenylboronic acid 2,6-Difluoro-3-methoxybenzeneboronic acid 4-ETHOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 2 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID 4-PROPOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 4-METHOXY-2,3,5,6-TETRAFLUOROPHENYLBORO& 4-BUTOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID 4-ISOPROPOXY-2,3,5,6-TETRAFLUOROBENZENEBORONIC ACID

  • 2,6-Difluoro-4-methoxybenzeneboronic acid
  • Difluoro-4-Methoxyphenylboronic
  • 6-DIFLUORO-4-METHOXYPHENYLBORONIC ACID
  • 2,6-Difluoro-4-Methoxyphenylboronic acid >=95%
  • 2,6-Difluoro-4-methoxyphenylboronic Acid (contains varying amounts of Anhydride)
  • 2,6-Difluoro-4-methoxyphenylboronicAcid(containsvaryingamountsofAnhydride)&gt
  • Boronic acid, (2,6-difluoro-4-methoxyphenyl)-
  • 26-Difluoro-4-MethoxyphenylboronicAci
  • Boronic acid, B-(2,6-difluoro-4-methoxyphenyl)-
  • 406482-20-0
  • Aryl
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Boronic Acids
  • blocks
  • BoronicAcids
  • FluoroCompounds