CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

Product Name: CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)
CAS No.: 144750-42-5
Chemical Name: CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)
Synonyms: Clopidogrel EP I;Clopidogrel USP RC A;Clopidogrel ImpurityCl;Clopidogrel EP IMpurity-A;Clopidogrel Impurity A（EP）;Clopidogrel Impurity 10 HCl;Clopidogrel EP Impurity A HCl;Clopidogrel Related CoMpound A;Clopidogrel acid hydrochloride;Clopidogrel-related impurities A
CBNumber: CB7505771
Molecular Formula: C15H14ClNO2S.ClH
Formula Weight: 344.26
MOL File: 144750-42-5.mol

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CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Property

Melting point:: 147-155°C (dec.)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: powder
color: Off-White to Pale Yellow
optical activity: 49.64°(C=0.164g/100mI, MEOH, 20°C, 589nm)
Stability:: Hygroscopic

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Safety

HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1990
Product name: Clopidogrel Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 40mg
Price: $869
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1140586
Product name: Clopidogrel Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $1460
Updated: 2025/07/31

Cayman Chemical

Product number: 17871
Product name: Clopidogrel Carboxylic Acid (hydrochloride)
Purity: ≥95%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17871
Product name: Clopidogrel Carboxylic Acid (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 17871
Product name: Clopidogrel Carboxylic Acid (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $380
Updated: 2024/03/01

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CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Chemical Properties,Usage,Production

Uses

Clopidogrel Carboxylic Acid Hydrochloride (Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A) is the hydrochloride salt of a metabolite of the drug Clopidogrel.

Synthesis

144457-28-3

144750-42-5

Example 6: Preparation of (S)-(+)-α-(2-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-acetic acid hydrochloride (Formula (III) hydrochloride) 1. 61 g of (S)-(+)-α-(2-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-acetic acid (the product of Example 5) was dissolved in a solvent mixture of 300 mL of acetone and 15 mL of methanol, and was heated to 40° C. to dissolve completely. 2. 16.4 mL of concentrated hydrochloric acid was slowly added to the above solution, after which the reaction mixture was stirred continuously at room temperature for 2 hours. 3. the reaction mixture was cooled to below 5 °C and kept at this temperature for at least 2 hours to promote crystallization. 4. The precipitated crystals were collected by filtration, washed with 100 mL of cold acetone and subsequently dried under reduced pressure at 40 °C to afford 61 g of the title compound as a white to pale yellow solid (yield: 90%). Product Characterization. - Melting point: 200-201°C - Spin: [α]D20 +64.87° (c=1%, MeOH) - Optical purity: 99.5% ee (HPLC) - 1H-NMR (DMSO-d6, ppm): δ 3.10 (s, 3H), 3.47 (s, 2H), 4.30 (s, 2H), 5.54 (s, 1H), 6.91 (d, 1H, J=4.8Hz), 7.44 (d, 1H, J=4.8Hz), 7.46-7.58 (m, 2H), 7.65 (d, 1H, J=7.4Hz), 7.65 (d, 1H, J=7.4Hz), 7.65 (d, 1H, J=7.4Hz). J=7.4 Hz), 7.97 (d, 1H, J=7.1 Hz) - 13C-NMR (DMSO-d6, ppm): δ 21.78, 48.81, 50.17, 65.43, 125.04, 125.54, 127.99, 128.29, 128.36, 130.37, 130.46, 131.49, 132.02, 134.43, 167.53 - IR (KBr, cm-1): 3435, 3114, 1728

References

[1] Patent: US2008/214821, 2008, A1. Location in patent: Page/Page column 5
[2] Patent: WO2006/137628, 2006, A1. Location in patent: Page/Page column 13

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

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CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) Suppliers

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View Lastest Price from CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) manufacturers

Career Henan Chemical Co

Product: CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) 144750-42-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%HPLC
Supply Ability: 200KG
Release date: 2020-02-01

144750-42-5, CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)Related Search:

rac-Clopidogrel Carboxylic Acid Ethyl-S-(+)-Clopidogrel Sulfate Clopidogrel

Clopidogrel Impurity 2/Clopidogrel EP Impurity A HCl/(S)-Clopidogrel Acid Hydrochloride/(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

Clopidogrel EP Impurity A HCl

CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

Clopidogrel Related Compound A (20 mg) ((S)-(ochlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-aceticv acid, hydrochloride)

(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride

Clopidogrel Related CoMpound A

Clopidogrel USP Related CoMpound A

Clopidogrel acid hydrochloride

Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)-

Clopidogrel carboxylic acid Impurity

alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride

Clopidogrel EP IMpurity-A

Clopidogrel Carboxylic Acid Hydrochloride

(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

Clopidogrel Impurity 1 HCl(Clopidogrel EP Impurity A HCl)

(S)-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride

Clopidogrel EP impurity-A (USP RC A)

Clopidogrel-related impurities A

Clopidogrel USP RC A

(+)-(S)-(o-Chlorophenyl)-6,7-dihydrothieno3,2-cpyridine-5(4H)-acetic acid hydrochloride

(S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride? (Clopidogrel Impurity）

Clopidogrel Related Compound A (H0M124)

Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-ace (1140586)

Clopidogrel Carboxylic Acid Hydrochloride Salt

Clopidogrel Impurity A（EP）

Clopidogrel Related Compound A as Hydrochloride

Clopidogrel USP Related Compound A as Hydrochloride

Clopidogrel EP I

(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid,

Clopidogrel Hydrogen Sulfate Impurity A as Hydrochloride

Clopidogrel Impurity 10 HCl

Clopidogrel Related Compound A /imp A

Clopidogrel Hydrogen Sulfate EP Impurity A as Hydrochloride

Clopidogrel ImpurityCl

(2S)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetic Acid Hydrochloride (Clopidogre

Clopidogrel EP Impurity A Hydrochloride

(2S)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetic Acid Hydrochloride (Clopidogrel Acid Hydrochloride)

144750-42-5

1444750-42-5

34426

C15H14ClNO2SClH