2-BROMO-5-CHLOROBENZYL ALCOHOL
- Product Name
- 2-BROMO-5-CHLOROBENZYL ALCOHOL
- CAS No.
- 60666-70-8
- Chemical Name
- 2-BROMO-5-CHLOROBENZYL ALCOHOL
- Synonyms
- 2-Bromo-5-chlorobenzyl alcoho;2-BROMO-5-CHLOROBENZYL ALCOHOL;5-CHLORO-2-BROMO BENZYL ALCOHOL;2-bromo-5-chloroBenzenemethanol;(2-Bromo-5-chlorophenyl)methanol;Benzenemethanol, 2-bromo-5-chloro-
- CBNumber
- CB7507184
- Molecular Formula
- C7H6BrClO
- Formula Weight
- 221.48
- MOL File
- 60666-70-8.mol
2-BROMO-5-CHLOROBENZYL ALCOHOL Property
- Melting point:
- 81-83°C
- Boiling point:
- 290℃
- Density
- 1.685
- Flash point:
- 129℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.67±0.10(Predicted)
- form
- solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B682205
- Product name
- 2-Bromo-5-chlorobenzylAlcohol
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- FB30265
- Product name
- 2-Bromo-5-chlorobenzyl alcohol
- Packaging
- 10g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- FB30265
- Product name
- 2-Bromo-5-chlorobenzyl alcohol
- Packaging
- 2g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- 130772
- Product name
- 2-Bromo-5-chlorobenzylalcohol
- Packaging
- 1g
- Price
- $129
- Updated
- 2021/12/16
- Product number
- FB30265
- Product name
- 2-Bromo-5-chlorobenzyl alcohol
- Packaging
- 5G
- Price
- $157.5
- Updated
- 2021/12/16
2-BROMO-5-CHLOROBENZYL ALCOHOL Chemical Properties,Usage,Production
Uses
2-Bromo-5-chlorobenzyl Alcohol is used to prepare fluorodihydrohydroxy benzoxaborole for potential treatment of onychomycosis. It is also an intermediate used to synthesize morpholylureas as potent and selective inhibitors of AKR1C3.
Synthesis
21739-93-5
60666-70-8
Under nitrogen protection, 2-bromo-5-chlorobenzoic acid (17-1, 5.0 g, 21.23 mmol) was dissolved in BH3/THF solution (1 M, 85 mL) at a controlled temperature of 10 °C. After the addition was completed, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, methanol (30 mL) was added slowly at 0 °C to quench the reaction, after which the mixture was concentrated to dryness. The resulting residue was dissolved in methanol (100 mL) and concentrated again to dryness. This dissolution-concentration procedure was repeated twice to give 2-bromo-5-chlorobenzenemethanol (17-2) as a white solid (4.7 g, quantitative yield).
References
[1] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 295
[2] Patent: WO2012/131588, 2012, A1. Location in patent: Page/Page column 96; 108
[3] Chemical Communications, 2018, vol. 54, # 20, p. 2467 - 2470
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 15, p. 4447 - 4450
[5] Patent: US2007/265226, 2007, A1. Location in patent: Page/Page column 58
2-BROMO-5-CHLOROBENZYL ALCOHOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-5-CHLOROBENZYL ALCOHOL manufacturers
- Product
- 2-Bromo-5-chlorobenzyl alcohol 60666-70-8
- Price
- US $0.10-10.00/KG
- Min. Order
- 0.10000000149011612KG
- Purity
- 98%
- Supply Ability
- 200TONS
- Release date
- 2025-08-14
- Product
- 2-BROMO-5-CHLOROBENZYL ALCOHOL 60666-70-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- JD724
- Release date
- 2019-09-02