ChemicalBook > CAS DataBase List > 3-FLUORO-5-FORMYLBENZONITRILE

3-FLUORO-5-FORMYLBENZONITRILE

Product Name
3-FLUORO-5-FORMYLBENZONITRILE
CAS No.
1003708-42-6
Chemical Name
3-FLUORO-5-FORMYLBENZONITRILE
Synonyms
3-FLUORO-5-FORMYLBENZONITRILE;Benzonitrile, 3-fluoro-5-formyl-;4-Chloro-4-(trifluoromethyl)acetophenone
CBNumber
CB7534339
Molecular Formula
C8H4FNO
Formula Weight
149.12
MOL File
Mol file
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3-FLUORO-5-FORMYLBENZONITRILE Property

Boiling point:
205℃
Density 
1.25
Flash point:
77℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
Off-white
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Safety

HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
F532040
Product name
3-Fluoro-5-formylbenzonitrile
Packaging
1g
Price
$145
Updated
2021/12/16
AK Scientific
Product number
X8502
Product name
3-Fluoro-5-formylbenzonitrile
Packaging
250mg
Price
$32
Updated
2021/12/16
Matrix Scientific
Product number
067013
Product name
3-Fluoro-5-formylbenzonitrile
Purity
>95%
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
067013
Product name
3-Fluoro-5-formylbenzonitrile
Purity
>95%
Packaging
5g
Price
$250
Updated
2021/12/16
Apolloscientific
Product number
PC200339
Product name
3-Fluoro-5-formylbenzonitrile
Purity
98%
Packaging
5g
Price
$254
Updated
2021/12/16
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3-FLUORO-5-FORMYLBENZONITRILE Chemical Properties,Usage,Production

Uses

3-Fluoro-5-formylbenzonitrile is benzaldehyde based building block used as a reactant in catalyst-free synthesis of N-β-hydroxyethyl pyrroles and indoles via a domino [3+2] cycloaddition and ring-opening aromatization process.

Application

3-FLUORO-5-FORMYLBENZONITRILE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

3 -fluoro-5 -formylbenzonitrile : A solution of 3 -bromo-5 -fluorobenzonitrile(5.00 g, 25.0 mmol) in dry THF (25 mL) was cooled to 0 °C and 2M iPrMgCl (15.0 mL, 30.0 mmol) in THF was added dropwise over 5 minutes. The mixture was stirred at 0 °C for 15 minutes then at ambient temperature for 1 hour. The mixture was cooled to 0 °C and dry DMF (5.81 mL, 75.0 mmol) was added. The mixture was stirred for 17 hours during which time the temperature reached ambient temperature after 2 hours. The mixture was added to ice water (150 mL) and Et20 (100 mL). The biphasic mixture was stirred and treated with 6M HC1 to aqueous pH=3. The organic layer was removed and the aqueous layer extracted with Et20 (2X). The combined Et20 fractions were washed with saturated NaCl and dried over MgS04/activated carbon. The dried solution was filtered through a S1O2 plug eluting with Et20. The filtrate was concentrated to give the title compound as a yellow solid that was dried in vacuum (3.68 g, 99percent). 1H NMR (CDC13) δ 10.0 (s, 1H), 8.00 (s, 1H), 7.81-7.86 (m, 1H), 7.62-7.67 (m, 1H).

3-FLUORO-5-FORMYLBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-FLUORO-5-FORMYLBENZONITRILE manufacturers

Career Henan Chemical Co
Product
3-FLUORO-5-FORMYLBENZONITRILE 1003708-42-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

1003708-42-6, 3-FLUORO-5-FORMYLBENZONITRILERelated Search:


  • 3-FLUORO-5-FORMYLBENZONITRILE
  • Benzonitrile, 3-fluoro-5-formyl-
  • 4-Chloro-4-(trifluoromethyl)acetophenone
  • 1003708-42-6