ChemicalBook > CAS DataBase List > CDK4/6-IN-2
CDK4/6-IN-2
- Product Name
- CDK4/6-IN-2
- CAS No.
- 1800506-48-2
- Chemical Name
- CDK4/6-IN-2
- Synonyms
- AM24679P4;CDK4/6-IN-2;CDK4/6 inhibitor 2;Cyclin dependent kinase,CDK-4/6-IN-2,CDK,CDK4/6 IN 2,CDK4/6IN2,inhibit,Inhibitor;5-((4-ethylpiperazin-1-yl)methyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyridin-2-yl)pyrimidin-2-amine;2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]-
- CBNumber
- CB75419703
- Molecular Formula
- C27H32F2N8
- Formula Weight
- 506.59
- MOL File
- 1800506-48-2.mol
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CDK4/6-IN-2 Property
- Boiling point:
- 665.2±65.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 5.2 mg/mL (10.26 mM)
- pka
- 7.67±0.10(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0083151
- Product name
- CDK4/6-IN-2
- Purity
- 99.82%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0083151
- Product name
- CDK4/6-IN-2
- Purity
- 99.82%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0083151
- Product name
- CDK4/6-IN-2
- Purity
- 99.82%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0083151
- Product name
- CDK4/6-IN-2
- Purity
- 99.82%
- Packaging
- 100mg
- Price
- $2650
- Updated
- 2021/12/16
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CDK4/6-IN-2 Chemical Properties,Usage,Production
Description
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1]. CDK4|2.7 nM (IC50)|CDK6|16 nM (IC50)
CDK4/6-IN-2 inhibits H358, H441, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells with IC50s of 290.9, 147.8, 260.5, 139, 36.98, 162.5, and 316.4 nM, respectively[1].
References
[1]. Frank Wu, et al. Kinase inhibitor and use thereof. US20180000819A1.
CDK4/6-IN-2 Preparation Products And Raw materials
Raw materials
Preparation Products
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