ChemicalBook > CAS DataBase List > NLX-204
NLX-204
- Product Name
- NLX-204
- CAS No.
- 2170405-10-2
- Chemical Name
- NLX-204
- Synonyms
- NLX-204;NLX-204 HCl;Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[2-(2-pyridinyloxy)ethyl]amino]methyl]-1-piperidinyl]-
- CBNumber
- CB75476780
- Molecular Formula
- C20H22ClF2N3O2
- Formula Weight
- 409.86
- MOL File
- 2170405-10-2.mol
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NLX-204 Property
- Boiling point:
- 559.6±50.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- pka
- 8.88±0.20(Predicted)
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- DC22176
- Product name
- NLX-204
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1200
- Updated
- 2021/12/16
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NLX-204 Chemical Properties,Usage,Production
Description
NLX-204 is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist with pKi = 10.19. NLX-204 displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein. Preliminary in vivo studies confirmed its promising pharmacokinetic profile. NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
NLX-204 Preparation Products And Raw materials
Raw materials
Preparation Products
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