Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-

Product Name: Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-
CAS No.: 1832578-30-9
Chemical Name: Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-
Synonyms: MLT-748;MLT 748,MLT748;MLT-748 ，S8898;1-(5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-chloro-7-((1R,2R)-1,2-dimethoxypropyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea;Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-
CBNumber: CB75488020
Molecular Formula: C19H19Cl2N9O3
Formula Weight: 492.32
MOL File: 1832578-30-9.mol

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Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- Property

Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 200 mg/mL (406.24 mM; Need ultrasonic)
form: Solid
pka: 7.78±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087009
Product name: MLT-748
Purity: 99.91%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0087009
Product name: MLT-748
Purity: 99.91%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0087009
Product name: MLT-748
Purity: 99.91%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0087009
Product name: MLT-748
Purity: 99.91%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

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Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- Chemical Properties,Usage,Production

Uses

MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM[1].

References

[1] Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313. DOI:10.1038/s41589-018-0222-1

Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]- Suppliers

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1832578-30-9, Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-Related Search:

Urea, N-[2-chloro-7-[(1R,2R)-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-N'-[5-chloro-6-(2H-1,2,3-triazol-2-yl)-3-pyridinyl]-

MLT-748

MLT 748,MLT748

1-(5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-chloro-7-((1R,2R)-1,2-dimethoxypropyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea

MLT-748 ，S8898

1832578-30-9

C19H19Cl2N9O3