ChemicalBook > CAS DataBase List > 1V209

1V209

Product Name
1V209
CAS No.
1062444-54-5
Chemical Name
1V209
Synonyms
1V209;TLR7 agonist T7;1V209, 10 mM in DMSO;1V209(TLR7 agonist T7);TLR7 agonist T7 (1V209);1V209 (TLR7 agonist T7) ，S0078;2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine;4-[[6-Amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9(8H)-yl]methyl]benzoic Acid;4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7，8-dihydro-9H-purin-9-yl)methyl)benzoic acid;Benzoic acid, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-
CBNumber
CB75583509
Molecular Formula
C16H17N5O5
Formula Weight
359.34
MOL File
1062444-54-5.mol
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1V209 Property

Density 
1.466±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 83.33 mg/mL (231.90 mM)
form 
Solid
pka
4.23±0.10(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0085942
Product name
1V209
Purity
99.52%
Packaging
5mg
Price
$115
Updated
2021/12/16
ChemScene
Product number
CS-0085942
Product name
1V209
Purity
99.52%
Packaging
10mg
Price
$195
Updated
2021/12/16
ChemScene
Product number
CS-0085942
Product name
1V209
Purity
99.52%
Packaging
25mg
Price
$410
Updated
2021/12/16
ChemScene
Product number
CS-0085942
Product name
1V209
Purity
99.52%
Packaging
50mg
Price
$700
Updated
2021/12/16
ChemScene
Product number
CS-0085942
Product name
1V209
Purity
99.52%
Packaging
100mg
Price
$1210
Updated
2021/12/16
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1V209 Chemical Properties,Usage,Production

Uses

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity[1][2].

in vivo

The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration[1].

IC 50

TLR7

References

[1] Battistella C, et al. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec;8(23):e1901105. DOI:10.1002/adhm.201901105
[2] Shinchi H, et al. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19;26(8):1713-23. DOI:10.1021/acs.bioconjchem.5b00285

1V209 Preparation Products And Raw materials

Raw materials

Preparation Products

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1V209 Suppliers

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1062444-54-5, 1V209Related Search:


  • 1V209
  • TLR7 agonist T7
  • Benzoic acid, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-
  • 4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7，8-dihydro-9H-purin-9-yl)methyl)benzoic acid
  • 1V209(TLR7 agonist T7)
  • TLR7 agonist T7 (1V209)
  • 2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine
  • cell,polysaccharides,IP-10,intravenous,MCP-1,Tumor,1V-209,IL-6,1V209,Toll-like Receptor (TLR),conjugate,Inhibitor,cancer,TNFα,inhibit
  • 4-[[6-Amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9(8H)-yl]methyl]benzoic Acid
  • 1V209, 10 mM in DMSO
  • 1V209 (TLR7 agonist T7) ，S0078
  • 1062444-54-5