VU6005806
- Product Name
- VU6005806
- CAS No.
- 2180914-37-6
- Chemical Name
- VU6005806
- Synonyms
- VU6005806;AZN-00016130;VU6005806,VU-6005806;Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-3-methoxy-4-methyl-N-[1-[5-(trifluoromethyl)-2-pyrimidinyl]-3-azetidinyl]-
- CBNumber
- CB75821342
- Molecular Formula
- C17H16F3N7O2S
- Formula Weight
- 439.41
- MOL File
- 2180914-37-6.mol
VU6005806 Property
- Density
- 1.59±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 11.44±0.20(Predicted)
VU6005806 Chemical Properties,Usage,Production
Description
VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
Uses
VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1].
References
[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.
VU6005806 Preparation Products And Raw materials
Raw materials
Preparation Products
VU6005806 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58