VU6005806

Product Name: VU6005806
CAS No.: 2180914-37-6
Chemical Name: VU6005806
Synonyms: VU6005806;AZN-00016130;VU6005806,VU-6005806;Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-3-methoxy-4-methyl-N-[1-[5-(trifluoromethyl)-2-pyrimidinyl]-3-azetidinyl]-
CBNumber: CB75821342
Molecular Formula: C17H16F3N7O2S
Formula Weight: 439.41
MOL File: 2180914-37-6.mol

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VU6005806 Property

Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 11.44±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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VU6005806 Chemical Properties,Usage,Production

Description

VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1]. IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]

References

[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.

VU6005806 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU6005806 Suppliers

China 3 United States 1 Global 4

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32080
Advantage: 58

2180914-37-6, VU6005806Related Search:

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide Benzamide, 4-(cyclopropylmethoxy)-3-methoxy-N-[2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl]- N-[1-(2-Fluorophenyl)-3-phenyl-1H-pyrazol-5-yl]-4-nitrobenzamide VU6010608

VU6005806

AZN-00016130

VU6005806,VU-6005806

Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-3-methoxy-4-methyl-N-[1-[5-(trifluoromethyl)-2-pyrimidinyl]-3-azetidinyl]-

2180914-37-6