ChemicalBook > CAS DataBase List > GO-203
GO-203
- Product Name
- GO-203
- CAS No.
- 1222186-26-6
- Chemical Name
- GO-203
- Synonyms
- GO-203;GO-203 TFA;(6R,9R,12R,15R,18R,21R,24R,27R,30R,33S,36R,39S,42R,45R,48R,51R)-1,6-Diamino-51-(2-amino-2-oxoethyl)-36-(3-amino-3-oxopropyl)-48-(4-aminobutyl)-9,12,15,18,21,24,27,30,42,45-decakis(3-guanidinopropyl)-1-imino-33,39-bis(mercaptomethyl)-7,10,13,16,19,22,25,28,31,34,37,40,43,46,49-pentadecaoxo-2,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazadopentacontan-52-oic acid 2,2,2-trifluoroacetic acid salt
- CBNumber
- CB75822561
- Molecular Formula
- C89H171F3N52O21S2
- Formula Weight
- 2426.81
- MOL File
- 1222186-26-6.mol
More
Less
GO-203 Property
- form
- Solid
- color
- White to off-white
- Sequence
- d-{Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Cys-Gln-Cys-Arg-Arg-Lys-Asn} (TFA salt)
More
Less
GO-203 Chemical Properties,Usage,Production
Uses
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice[1][2].
in vivo
GO-203 (18 mg/kg/day; IP; for 28 days) TFA significantly inhibits growth of the COLO-205 tumors[2].
| Animal Model: | Four- to 6-week-old BALB/c nu/nu male/female mice with Colo-205 or SKCO-1 cells[2] |
| Dosage: | 18 mg/kg |
| Administration: | IP; daily; for 28 days |
| Result: | Significantly inhibited growth of the COLO-205 tumors. These tumors regressed completely by the end of treatment (day 28) and there was no evidence for regrowth by day 180. |
IC 50
PI3K
References
[1] Masanori Hasegawa, et al. Intracellular Targeting of the Oncogenic MUC1-C Protein with a Novel GO-203 Nanoparticle Formulation. Clin Cancer Res. 2015 May 15;21(10):2338-47. DOI:10.1158/1078-0432.CCR-14-3000
[2] Rehan Ahmad, et al. Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer. Mol Cancer. 2017 Feb 2;16(1):33. DOI:10.1186/s12943-017-0608-9
GO-203 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
GO-203 Suppliers
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4802
- Advantage
- 58
- Tel
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7408
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 15397062932
- sales1@gotopbio.com
- Country
- China
- ProdList
- 2923
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 59936
- Advantage
- 58
- Tel
- 0571-0571-88211921 19105816207
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5144
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6979
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- 15888826472@163.com
- Country
- China
- ProdList
- 2729
- Advantage
- 58
- Tel
- 15318089928
- alex@hanhonggroup.com
- Country
- China
- ProdList
- 4604
- Advantage
- 58
- Tel
- 13770887460
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1354
- Advantage
- 58
- Tel
- 17751201929
- office@combiosz.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4880
- Advantage
- 58
- Tel
- 19135651983
- 18611134419@163.com
- Country
- China
- ProdList
- 4416
- Advantage
- 58
- Tel
- 029-81145305 17791533577
- 1021@dideu.com
- Country
- China
- ProdList
- 10009
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 48457
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- bptsales@163.com
- Country
- China
- ProdList
- 3834
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 400-025-6535
- sales@adooq.cn
- Country
- China
- ProdList
- 6215
- Advantage
- 58
- Tel
- +8619375158599
- info@molchanges.com
- Country
- China
- ProdList
- 5218
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10405
- Advantage
- 58
- Tel
- +8618327326525
- masar@topule.com
- Country
- China
- ProdList
- 8467
- Advantage
- 58
- Tel
- 13969187155
- Country
- CHINA
- ProdList
- 119
- Advantage
- 58
- Tel
- 18689410811
- Country
- CHINA
- ProdList
- 178
- Advantage
- 58
- Tel
- 18826403302
- Country
- CHINA
- ProdList
- 111
- Advantage
- 58
- Tel
- 18925065404
- Country
- CHINA
- ProdList
- 168
- Advantage
- 58
- Tel
- 18829918890
- Country
- CHINA
- ProdList
- 186
- Advantage
- 58
- Tel
- 13269979963
- 1565439254@qq.com
- Country
- CHINA
- ProdList
- 195
- Advantage
- 58
- Tel
- 13532174601
- Country
- CHINA
- ProdList
- 109
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58