(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
- Product Name
- (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
- CAS No.
- 1016167-99-9
- Chemical Name
- (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate
- Synonyms
- (S)-N-Boc-1-(3-piperidyl)methanamine;(R)-3-(Boc-aminomethyl)piperidine,97%;tert-butyl (S)-(piperidin-3-ylmethyl)carbamate;S-3-N-Boc-Aminomethyl Piperidine Hydrochloride;tert-Butyl N-[(3S)-3-Piperidinylmethyl]carbamate;tert-Butyl-N-[(3S)-piperidine-3ylmethyl)] carbamate;Carbamic acid, N-[(3S)-3-piperidinylmethyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB75832009
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 1016167-99-9.mol
(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4H56-1-S03
- Product name
- tert-Butyl N-[(3S)-piperidin-3-ylmethyl]carbamate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 0420AA
- Product name
- (S)-tert-butyl(piperidin-3-ylmethyl)carbamate
- Packaging
- 5g
- Price
- $242
- Updated
- 2021/12/16
- Product number
- CS-W006519
- Product name
- (S)-tert-butyl(piperidin-3-ylmethyl)carbamate
- Packaging
- 5g
- Price
- $255
- Updated
- 2021/12/16
- Product number
- AS55017-3S
- Product name
- (S)-3-(Boc-aminomethyl)piperidine
- Purity
- 97+% ee
- Packaging
- 5G
- Price
- $260
- Updated
- 2021/12/16
- Product number
- 112215
- Product name
- (S)-3-(Boc-aminomethyl)-piperidine
- Packaging
- 1g
- Price
- $284
- Updated
- 2021/12/16
(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate Chemical Properties,Usage,Production
Synthesis
142643-29-6
1016167-99-9
The general procedure for the synthesis of tert-butyl (S)-(piperidin-3-ylmethyl)carbamate from 3-Boc-aminomethylpiperidine is as follows:Example 4 Synthesis of (3S)-N-(tert-butoxycarbonyl)-3-aminomethylpiperidine (Compound 5): N-(tert-butoxycarbonyl)-3-aminomethylpiperidine (10 g, 47 mmol, 1 equiv), (-)-O,O' -di-β-tosyl-L-tartaric acid (15.52 g, 47 mmol, 1 eq.) were mixed with dry methanol (100 ml) and slowly heated to reflux to form a homogeneous solution. The reaction mixture was cooled to room temperature and stirred for 5-6 hours. The resulting white solid was filtered and washed with a minimal amount of anhydrous methanol. The crude product was purified by recrystallization from methanol. The resulting compound was suspended in distilled water (25 ml) and cooled to 0°C. 10% sodium carbonate solution (100 ml) was added in batches until the reaction mixture was basic and stirring was continued for 10 minutes. The reaction mixture was extracted with ethyl acetate (5 x 50 ml), the organic layer was separated and concentrated under reduced pressure after drying to give the target compound 3. Yield: 3.28 g (65%). [α]D: +11.03 (c=0.10, methanol). Melting point: 64-66°C. IR (pure): 3360, 2972, 1703, 1519, 1455, 1365, 1255, 1172 cm-1. 1H NMR (CDCl3, 300MHz) δ: 1.01-1.21 (m, 2H, H-4); 1.39 (s, 9H, -OC(CH3)3); 1.57- 1.72 (m, 3H, H-3, H-5); 2.20-2.31 (m, 1H, CHaNHBoc); 2.49-2.56 (m, 1H, CHbNHBoc); 2.90-3.03 (m, 4H, H-2, H-4); 4.77 (brs, 1H, NH).13C NMR (CDCl3, 300MHz) δ : 26.56, 29.03, 29.58, 38.44, 44.99, 47.46, 51.16, 79.73, 156.72. FAB MS (m/z): 215 (M+1, 114).
References
[1] Patent: WO2012/104866, 2012, A1. Location in patent: Page/Page column 17-18
(S)-Tert-butyl (piperidin-3-ylmethyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-Tert-butyl (piperidin-3-ylmethyl)carbamate manufacturers
- Product
- S-3-N-BOC-AMINOMETHYL PIPERIDINE-HCl 1016167-99-9
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07