ChemicalBook > CAS DataBase List > VTP50469

VTP50469

Product Name: VTP50469
CAS No.: 2169916-18-9
Chemical Name: VTP50469
Synonyms: VTP50469;VTP50469, 10 mM in DMSO;5-Fluoro-N,N-diisopropyl-2-((4-(7-((trans-4-(methylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide;Benzamide, 5-fluoro-N,N-bis(1-methylethyl)-2-[[4-[7-[[trans-4-[(methylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-;Menin-MLL,leukemia,survival,VTP 50469,Epigenetic Reader Domain,antiproliferative,Apoptosis,Inhibitor,protein-protein,VTP-50469,inhibit,VTP50469,differentiation
CBNumber: CB75839891
Molecular Formula: C32H47FN6O4S
Formula Weight: 630.82
MOL File: 2169916-18-9.mol

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VTP50469 Property

Boiling point:: 735.2±70.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
solubility: DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
form: Solid
pka: 10.97±0.40(Predicted)
color: White to light yellow
InChIKey: ADHHOUXZPBYYSU-YOCNBXQISA-N
SMILES: C(N(C(C)C)C(C)C)(=O)C1=CC(F)=CC=C1OC1=CN=CN=C1N1CC2(CCN(C[C@@H]3CC[C@@H](NS(C)(=O)=O)CC3)CC2)C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0077527
Product name: VTP50469
Purity: 99.41%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0077527
Product name: VTP50469
Purity: 99.41%
Packaging: 10mg
Price: $780
Updated: 2021/12/16

ChemScene

Product number: CS-0077527
Product name: VTP50469
Purity: 99.41%
Packaging: 50mg
Price: $2150
Updated: 2021/12/16

ChemScene

Product number: CS-0077527
Product name: VTP50469
Purity: 99.41%
Packaging: 100mg
Price: $2850
Updated: 2021/12/16

DC Chemicals

Product number: 012382
Product name: VTP50469
Packaging: 003
Price: $3600
Updated: 2021/12/16

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VTP50469 Chemical Properties,Usage,Production

Uses

VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity[1][2].

in vivo

VTP50469 (15-60 mg/kg; oral administration; twice a day; for 28 days; NSG mice) treatment is highly efficacious across all dosage levels and all treatment groups have a significant survival advantage. Mice dosed at 30 and 60 mg/kg VTP50469 extends survival advantage^[1].

Animal Model:	Unconditioned immunodeficient (NSG) mice with MV4;11 cells^[1]
Dosage:	15 mg/kg, 30 mg/kg, and 60 mg/kg
Administration:	Oral administration; twice a day; for 28 days
Result:	Was highly efficacious across all dosage levels and all treatment groups had a significant survival advantage over the control group.

References

[1] Krivtsov AV, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 Dec 9;36(6):660-673.e11. DOI:10.1016/j.ccell.2019.11.001

[2] Andrei V. Krivtsov, et al. Abstract 4958: VTP50469 is a novel, orally available menin-MLL1 inhibitor effective against MLL-rearranged and NPM1-mutant leukemia. Cancer Resceach. July 2018.Volume 78, Issue 13 Supplement.

VTP50469 Preparation Products And Raw materials

Raw materials

Preparation Products

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2169916-18-9, VTP50469Related Search:

VTP50469

Benzamide, 5-fluoro-N,N-bis(1-methylethyl)-2-[[4-[7-[[trans-4-[(methylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-

Menin-MLL,leukemia,survival,VTP 50469,Epigenetic Reader Domain,antiproliferative,Apoptosis,Inhibitor,protein-protein,VTP-50469,inhibit,VTP50469,differentiation

5-Fluoro-N,N-diisopropyl-2-((4-(7-((trans-4-(methylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide

VTP50469, 10 mM in DMSO

2169916-18-9

2169919-18-9