ACBI1

ChemicalBook > CAS DataBase List > ACBI1

Product Name: ACBI1
CAS No.: 2375564-55-7
Chemical Name: ACBI1
Synonyms: ACBI1;PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1;N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide;(2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide
CBNumber: CB75848938
Molecular Formula: C49H58FN9O7S
Formula Weight: 936.12
MOL File: 2375564-55-7.mol

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ACBI1 Property

Boiling point:: 1144.1±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
pka: 6.22±0.30(Predicted)
form: Solid
color: White to yellow
InChIKey: IVARZBJJMMUJHI-SSIILETPNA-N
SMILES: NC1N=NC(C2C=CC=CC=2O)=CC=1N1CCN(CC2C=CC(OCCOC3C=C(C4SC=NC=4C)C=CC=3CNC([C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)(C)C)NC(C3(CC3)F)=O)=O)=CC=2)CC1 |&1:42,44,50,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0099076
Product name: ACBI1
Purity: 98.21%
Packaging: 1mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0099076
Product name: ACBI1
Purity: 98.21%
Packaging: 5mg
Price: $4000
Updated: 2021/12/16

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ACBI1 Chemical Properties,Usage,Production

Definition

ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and PBRM1 degrader with DC50s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity and can induce apoptosis. It induced anti-proliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells and acute myeloid leukemia cells dependent on SMARCA4 ATPase activity[1].

References

[1] William Farnaby. “BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.” Nature chemical biology 15 7 (2019): 672–680.
[2] M. Koegl. “Abstract 3849: Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer.” Experimental and Molecular Therapeutics 36 1 (2019).

ACBI1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ACBI1 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: ACBI1 2375564-55-7
Price: US $200.00-100.00/MG
Min. Order: 1MG
Purity: 98
Supply Ability: 100G
Release date: 2024-11-18

2375564-55-7, ACBI1Related Search:

ACBI1

PROTACs,anti-proliferative,ACBI 1,Epigenetic Reader Domain,ACBI1,Inhibitor,Apoptosis,inhibit,ACBI-1

N-[(1-Fluorocyclopropyl)carbonyl]-3-methyl-L-valyl-(4R)-N-[2-{2-[4-({4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinyl}methyl)phenoxy]ethoxy}-4-(4-methyl-1,3-thiazol-5-yl)benzyl]-4-hydroxy-L-prolinamide

(2S,4R)-N-(2-(2-(4-((4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide

2375564-55-7

375564-55-7

C49H58FN9O7S