MAP4K4-IN-17

Product Name: MAP4K4-IN-17
CAS No.: 1811510-58-3
Chemical Name: MAP4K4-IN-17
Synonyms: Compound 17;MAP4K4-IN-3;MAP4K4-IN-17;MAP4K4-IN-3, 10 mM in DMSO;5-(6-Amino-5-(4-chlorophenyl)pyridin-3-yl)pyrimidin-2-amine;2-Pyrimidinamine, 5-[6-amino-5-(4-chlorophenyl)-3-pyridinyl]-;MAP4K,MAPK Kinase Kinase Kinase,Inhibitor,MAP4K4 IN 3,MAP4K4IN3,inhibit,MAP-4K4-IN-3
CBNumber: CB75867412
Molecular Formula: C15H12ClN5
Formula Weight: 297.74
MOL File: 1811510-58-3.mol

More

Less

MAP4K4-IN-17 Property

Boiling point:: 548.1±60.0 °C(Predicted)
Density: 1.377±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 10 mg/mL (33.59 mM; ultrasonic and warming and heat to 60°C)
pka: 4.31±0.50(Predicted)
form: Solid
color: Off-white to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

MAP4K4-IN-17 Chemical Properties,Usage,Production

Uses

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].

in vivo

Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3^[2].

IC 50

MAP4K4: 14.9 nM (IC₅₀)

References

[1] Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. DOI:10.1021/acsmedchemlett.5b00215
[2] Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125. DOI:10.1021/acs.jmedchem.8b00152

MAP4K4-IN-17 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MAP4K4-IN-17 Suppliers

China 22 United States 3 Global 25

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4795
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10408
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4857
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24964
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 18100677375
Email: sales@szzxbio.com
Country: China
ProdList: 2993
Advantage: 58

1811510-58-3, MAP4K4-IN-17Related Search:

MAP4K4-IN-17

MAP4K4-IN-3

2-Pyrimidinamine, 5-[6-amino-5-(4-chlorophenyl)-3-pyridinyl]-

Compound 17

MAP4K,MAPK Kinase Kinase Kinase,Inhibitor,MAP4K4 IN 3,MAP4K4IN3,inhibit,MAP-4K4-IN-3

5-(6-Amino-5-(4-chlorophenyl)pyridin-3-yl)pyrimidin-2-amine

MAP4K4-IN-3, 10 mM in DMSO

1811510-58-3