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Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-

Product Name
Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-
CAS No.
2095886-80-7
Chemical Name
Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-
Synonyms
NV-5138;NV-5138, 10 mM in DMSO;(2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid;Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-;inhibit,Inhibitor,NV-5138,mTOR,NV5138,Mammalian target of Rapamycin,NV 5138
CBNumber
CB75970354
Molecular Formula
C7H13F2NO2
Formula Weight
181.18
MOL File
2095886-80-7.mol
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Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Property

storage temp. 
Store at -20°C,unstable in solution, ready to use.
solubility 
DMSO: 10mM
form 
A solid
color 
White to off-white
InChI
InChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1
InChIKey
HRFIMCJTDKEPPV-BYPYZUCNSA-N
SMILES
C(O)(=O)[C@@H](N)CC(C)(C)C(F)F
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Chemical Properties,Usage,Production

Uses

NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies[1][2].

in vivo

NV-5138 is found to be essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h determined following intravenous and oral dosing in rats[1].
NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC[2].
NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects[2].

Animal Model:Male Sprague-Dawley rats weighing 250-260 g[2].
Dosage:40, 80, 160 mg/kg.
Administration:PO, single dose (160 mg/kg) or daily for a total of 7 days (40, 80 mg/kg).
Result:Produced antidepressant effects.
Animal Model:Male Sprague–Dawley (SD) rats weighed 250-400 g[1].
Dosage:1 mg/kg, 5 mg/kg (Pharmacokinetic Design).
Administration:I.V at 1 mg/kg and PO at 5 mg/kg.
Result:Essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h.

References

[1] Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. DOI:10.1038/s41598-019-40693-5
[2] Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. DOI:10.1172/JCI126859

Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Suppliers

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2095886-80-7, Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-Related Search:


  • Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-
  • NV-5138
  • (2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid
  • inhibit,Inhibitor,NV-5138,mTOR,NV5138,Mammalian target of Rapamycin,NV 5138
  • NV-5138, 10 mM in DMSO
  • 2095886-80-7