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Methotrexate α-tert-Butyl Ester

Product Name
Methotrexate α-tert-Butyl Ester
CAS No.
79640-70-3
Chemical Name
Methotrexate α-tert-Butyl Ester
Synonyms
Methotrexate Impurity 8;Methotrexate a-tert-Butyl Ester;Methotrexate α-tert-Butyl Ester;(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid;L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester
CBNumber
CB76091801
Molecular Formula
C24H30N8O5
Formula Weight
510.55
MOL File
79640-70-3.mol
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Methotrexate α-tert-Butyl Ester Property

Melting point:
>211°C (dec.)
Density 
1.377±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
4.43±0.10(Predicted)
color 
Pale Yellow to Orange
InChIKey
HTMMDBDGHQUHPW-INIZCTEOSA-N
SMILES
NC1=NC(=NC2N=CC(=NC=21)CN(C1C=CC(=CC=1)C(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C)C)N
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M260750
Product name
Methotrexateα-tert-ButylEster
Packaging
10mg
Price
$95
Updated
2021/12/16
TRC
Product number
M260750
Product name
Methotrexateα-tert-ButylEster
Packaging
25mg
Price
$205
Updated
2021/12/16
TRC
Product number
M260750
Product name
Methotrexateα-tert-ButylEster
Packaging
100mg
Price
$650
Updated
2021/12/16
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Methotrexate α-tert-Butyl Ester Chemical Properties,Usage,Production

Uses

Methotrexate α-tert-Butyl Ester is an intermediate to the synthesis of folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.

in vivo

Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice[1].
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo[1].

Animal Model:Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells)[1]
Dosage:30 mg/kg
Administration:Once per week for 2 weeks
Result:Showed a significant (63%) reduction in tumor size on day 12.

Methotrexate α-tert-Butyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Methotrexate α-tert-Butyl Ester Suppliers

Canada 1 China 30 India 2 United States 2 Global 35
Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581
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sales@chemhifuture.com
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China
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Tianjin shanhaijing medicine technology co., ltd
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15321929114
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yangtzechem@163.com
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China
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501
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ChemShuttle, Inc.
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0510-83588313-811 18800520310
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sales@chemshuttle.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghai GL Peptide Ltd.
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+86-21-61263340; 17609490614 13764994101
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021-61263399
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fisherwang@glschina.com
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China
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720
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010-60605840
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psaitong@jm-bio.com
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China
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Changzhou Chenhong Biotechnology Co., Ltd.
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+86-0519-85788828 +86-13775037613
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sales@chemrenpharm.com
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China
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4032
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing@energy-chemical.com
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China
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79640-70-3, Methotrexate α-tert-Butyl EsterRelated Search:


  • Methotrexate α-tert-Butyl Ester
  • (S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid
  • L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester
  • Methotrexate a-tert-Butyl Ester
  • Methotrexate Impurity 8
  • 79640-70-3