Mobocertinib succinate

ChemicalBook > CAS DataBase List > Mobocertinib succinate

Product Name: Mobocertinib succinate
CAS No.: 2389149-74-8
Chemical Name: Mobocertinib succinate
Synonyms: TAK788 succinate;788Succinic acid;AP32788 succinate;Mopotinib succinate;TAK-788 Succinic acid;Mobocertinib succinate;Mobocertinib succinate（TAK788）;obocertinib Succinate (TAK-788 Succinate);Mobocertinib Succinate (TAK-788 Succinate);isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate succinate
CBNumber: CB76183654
Molecular Formula: C36H45N7O8
Formula Weight: 703.8
MOL File: 2389149-74-8.mol

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Mobocertinib succinate Property

storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (35.52 mM; Need ultrasonic)
InChI: InChI=1S/C32H39N7O4.C4H6O4/c1-9-29(40)34-24-16-25(28(42-8)17-27(24)38(6)15-14-37(4)5)35-32-33-18-22(31(41)43-20(2)3)30(36-32)23-19-39(7)26-13-11-10-12-21(23)26;5-3(6)1-2-4(7)8/h9-13,16-20H,1,14-15H2,2-8H3,(H,34,40)(H,33,35,36);1-2H2,(H,5,6)(H,7,8)
InChIKey: YXYAEUMTJQGKHS-UHFFFAOYSA-N
SMILES: C(C(=O)O)CC(=O)O.C(C1=CN=C(NC2C=C(NC(=O)C=C)C(N(C)CCN(C)C)=CC=2OC)N=C1C1=CN(C)C2=CC=CC=C12)(=O)OC(C)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0114257
Product name: Mobocertinib(succinate)
Purity: 99.61%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-0114257
Product name: Mobocertinib(succinate)
Purity: 99.61%
Packaging: 25mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0114257
Product name: Mobocertinib(succinate)
Purity: 99.61%
Packaging: 50mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0114257
Product name: Mobocertinib(succinate)
Purity: 99.61%
Packaging: 100mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0114257
Product name: Mobocertinib(succinate)
Purity: 99.61%
Packaging: 500mg
Price: $950
Updated: 2021/12/16

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Mobocertinib succinate Chemical Properties,Usage,Production

Description

Mobocertinib (TAK-788) succinate is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib succinate potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib succinate can be used in NSCLC research.

Uses

Mobocertinib is an oral targeted therapy drug^[1].Mobocertinib is used to treat a certain type of non-small cell lung cancer (NSCLC) that cannot be removed by surgery and has spread to other parts of the body either during or after treatment with platinum chemotherapy medications.

Mechanism of action

Mobocertinib acts to inhibit EGFR exon 20 insertion mutations at a lower concentration than it does on wild-type proteins.

Side effects

Diarrhoea, rash, nausea, stomatitis, vomiting, decreased appetite, paronychia, fatigue, dry skin,musculoskeletal pain, increased amylase/lipase/creatinine, and decreased potassium/hemoglobin/magnesium/lymphocytes.

Synthesis

Mobocertinib succinate is prepared by the reaction of Isopropyl 2-chloro-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate in the presence of an inert atmosphere.

References

[1] IMRANMOHD. Discovery, Development, Inventions, and Patent Trends on Mobocertinib Succinate: The First-in-Class Oral Treatment for NSCLC with EGFR Exon 20 Insertions.[J]. Biomedicines, 2021. DOI:10.3390/biomedicines9121938.

Mobocertinib succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mobocertinib succinate manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: Mobocertinib succinate 2389149-74-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞99.5% by HPLC
Supply Ability: 100kg/month
Release date: 2023-02-18

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 788Succinic acid 2389149-74-8
Price: US $90.00-900.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-30

HEBEI Meijinnong Import And Export Trade Co.,LTD

Product: Mopotinib succinate 2389149-74-8
Price: US $10.00/g
Min. Order: 0.0010000000474974513g
Purity: >99%
Supply Ability: No upper limit
Release date: 2022-10-26

2389149-74-8, Mobocertinib succinateRelated Search:

Mobocertinib succinate

788Succinic acid

TAK788 succinate

TAK-788 Succinic acid

Mopotinib succinate

obocertinib Succinate (TAK-788 Succinate)

Mobocertinib Succinate (TAK-788 Succinate)

Mobocertinib succinate（TAK788）

AP32788 succinate

isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate succinate

2389149-74-8

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