PF-06256142

Product Name: PF-06256142
CAS No.: 1609583-14-3
Chemical Name: PF-06256142
Synonyms: PF-06256142;PF 06256142,PF06256142;Imidazo[1,2-a]pyrazine, 5-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-6-methyl-, (5S)-
CBNumber: CB76226308
Molecular Formula: C21H16N4O2
Formula Weight: 356.38
MOL File: 1609583-14-3.mol

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PF-06256142 Property

Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 200 mg/mL (514.88 mM; Need ultrasonic)
pka: 4.68±0.40(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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PF-06256142 Chemical Properties,Usage,Production

Biological Activity

PF-06256142 is a potent, selective, CNS-penetrant and orally active agonist of the D1 receptor, with an EC50 and Ki of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease[1]. PF-06256142 exhibits IC50 values of 10 μM)[1]. PF-06256142 exhibits high oral bioavailability (rat 85%) following oral administration (rat 5 mg/kg)[1].PF-06256142 exhibits terminal elimination half-life (rat 2.3 h) following intravenous administration (rat 5.0 mg/kg)[1].

References

[1]. Davoren JE, et al. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem. 2018 Nov 15.

PF-06256142 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06256142 Suppliers

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1609583-14-3, PF-06256142Related Search:

PF-06256142

PF 06256142,PF06256142

Imidazo[1,2-a]pyrazine, 5-[4-(furo[3,2-c]pyridin-4-yloxy)-2-methylphenyl]-6-methyl-, (5S)-

1609583-14-3