ChemicalBook > CAS DataBase List > 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE

7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE

Product Name: 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE
CAS No.: 203395-59-9
Chemical Name: 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE
Synonyms: Epiprazole impurity 44;Aripiprazole BroMo IMpurity;7-(4-Bromobutoxy)-1H-quinolin-2-one;7-(4-BroMobutoxy)-2(1H)-quinolinone;7-(4-bromobutoxy)quinolin-2(1H)-one;2(1H)-Quinolinone,7-(4- broMobutoxy)-;7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE;Aripiprazole Bromobutoxyquinolinone Analog;7-(4-Bromobutoxy)quinolin2(1H)-one / Dehydro Impurity;7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE (Related Reference)
CBNumber: CB7648430
Molecular Formula: C13H14BrNO2
Formula Weight: 296.16
MOL File: Mol file

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7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Property

Melting point:: 126-128 °C
Boiling point:: 475.3±45.0 °C(Predicted)
Density: 1.418±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Dichloromethane
form: Solid
pka: 11.21±0.70(Predicted)
color: Peachy

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1A02480
Product name: Aripiprazole Bromobutoxyquinolinone Analog
Purity: Pharmaceutical Analytical Impurity (PAI)
Packaging: 25mg
Price: $1260
Updated: 2025/07/31

TRC

Product number: B681980
Product name: 7-(4-Bromobutoxy)-quinoline-2(1H)-one
Packaging: 50mg
Price: $1230
Updated: 2021/12/16

AK Scientific

Product number: 9380AF
Product name: 7-(4-Bromobutoxy)-quinoline-2(1H)-one
Packaging: 1g
Price: $61
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19205
Product name: 7-(4-Bromobutoxy)-quinoline-2(1H)-one
Packaging: 2mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19205
Product name: 7-(4-Bromobutoxy)-quinoline-2(1H)-one
Packaging: 5mg
Price: $400
Updated: 2021/12/16

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7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Chemical Properties,Usage,Production

Chemical Properties

Peachy Solid

Uses

Aripiprazole Bromo Impurity

Synthesis

129722-34-5

203395-59-9

To a 500 mL two-necked round-bottomed flask equipped with a magnetic stirrer and argon protection was added 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone (5b, 10 g, 0.033 mol) and THF (200 mL). To the above mixture was added 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (30.4 g, 0.13 mol) at room temperature with continuous stirring until the reaction was complete (progress of the reaction was monitored by TLC). Upon completion of the reaction, THF was removed by evaporation under reduced pressure.The resulting residue was washed with water (200 mL) and extracted with ethyl acetate (3 x 100 mL). The organic layers were combined, washed with saturated saline, dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude product. The crude product was purified by column chromatography using ethyl acetate and hexane as eluents to afford the target compound 7-(4-bromobutoxy)-2(1H)-quinolinone (8b). Yield: 98.99% (9.8 g). 1H NMR (400 MHz, DMSO-d6) δ 11.57 (s, 1H), 7.77 (d, J = 9.4 Hz, 1H), 7.53 (d, J = 9.4 Hz, 1H), 6.83-6.69 (m, 2H), 6.27 (d, J = 9.6 Hz, 1H), 4.02 (t, J = 6.1 Hz, 2H), 3.59 (t, J = 6.6 Hz, 2H), 2.03-1.89 (m, 2H), 1.89-1.74 (m, 2H). 13C NMR (100 MHz, DMSO-d6): δ 162.67, 160.72, 141.05, 140.44, 129.69, 118.97, 113.77, 111.19, 99.05, 67.28, 35.26, 29.46, 27.74; δ 296 [t = 6.6 Hz], 2.03-1.89 (m, 2H), 1.89-1.74 (m, 2H). ESI-MS: 296 [M + H]+. HPLC purity: 99.26% [retention time: 11.545 min; detection wavelength: 210 nm; column: X Bridge C-18, 150×4.6 mm, particle size 5 μm; mobile phase: A) 0.1% TFA aqueous solution, B) acetonitrile; gradient program: 0 min/10% B, 3 min/10% B, 15 min/95% B, 23 min/95% B, 25 min/95% B, 25 min/95% B, 23 min/95% B, 23 min/95% B, 23 min/95% B, 23 min/95% B, 23 min/95% B. 23 min/95% B, 25 min/10% B, 30 min/10% B; Flow rate: 1.0 mL/min; Diluent: acetonitrile:water (80:20)]. The 1H NMR spectral data of compound 8b is in agreement with the values reported in the literature.

References

[1] Journal of Chemical Sciences, 2018, vol. 130, # 6,
[2] Synthetic Communications, 2007, vol. 37, # 24, p. 4337 - 4341

7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE Suppliers

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203395-59-9, 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONERelated Search:

Aripiprazole Aripiprazole N,N-Dioxide 1-(2,3-Dichlorophenyl)piperazine hydrochloride Aripiprazole iMpurity 4 Aripiprazole Impurity 7 HCl Aripiprazole impurity 20 Aripiprazole-d8 (Butyl-d8) Aripiprazole impurity 22 Aripiprazole Impurity 15 DEHYDRO ARIPIPRAZOLE Aripiprazole impurity 23 [[p-(2-methoxyethyl)phenoxy]methyl]oxirane 8-HYDROXY-3,4-DIHYDRO-2-QUINOLINONE 1-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-7-hydroxy-3,4-dihydrocarbostyril Aripiprazole Related CoMpound (5-(4-broMobutoxy)-3,4-dihydroquinolin-2(1H)-one) Aripiprazole Impurity 18 1-(2-Hydroxyethyl)piperazine Deschloroaripiprazole

7-(4-BroMobutoxy)-2(1H)-quinolinone

Aripiprazole BroMo IMpurity

2(1H)-Quinolinone,7-(4- broMobutoxy)-

7-(4-bromobutoxy)quinolin-2(1H)-one

7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE (Related Reference)

7-(4-Bromobutoxy)-1H-quinolin-2-one

Aripiprazole Bromo Impurity/ 7-(4-bromobutoxy)quinolin-2(1H)-one

7-(4-bromobutoxy)quinolin-2(1H)-one/ Aripiprazole Bromo Impurity

7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE

7-(4-Bromobutoxy)quinolin2(1H)-one / Dehydro Impurity

Epiprazole impurity 44

Brexpiprazole Impurity 16 7-(4-Bromobutoxy)-quinoline-2(1H)-one

Aripiprazole Bromobutoxyquinolinone Analog

203395-59-9

Aromatics Compounds

Aromatics

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