2-HYDROXY-5-BENZYLOXYACETOPHENONE
- Product Name
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE
- CAS No.
- 30992-63-3
- Chemical Name
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE
- Synonyms
- Odatero Impurity 4;2-HYDROXY-5-BENZYLOXYACETOPHENONE;5'-Benzyloxy-2'-hydroxyacetophenone;1-[2-Hydroxy-5-(phenylMethoxy)phenyl]ethanone;Ethanone, 1-[2-hydroxy-5-(phenylMethoxy)phenyl]-;1-(2-Hydroxy-5-phenylmethoxyphenyl)ethanone - [H92760];JR-13548, 1-(5-(Benzyloxy)-2-hydroxyphenyl)ethanone, 95%
- CBNumber
- CB7649114
- Molecular Formula
- C15H14O3
- Formula Weight
- 242.27
- MOL File
- 30992-63-3.mol
2-HYDROXY-5-BENZYLOXYACETOPHENONE Property
- Melting point:
- 64-66°C
- Boiling point:
- 391.2±27.0 °C(Predicted)
- Density
- 1.187±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform, Dichloromethane, Ethyl Acetate, Methanol
- form
- Solid
- pka
- 10.52±0.20(Predicted)
- color
- Yellow
Safety
- HS Code
- 2914390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H829870
- Product name
- 2-Hydroxy-5-benzyloxyacetophenone
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- H829870
- Product name
- 2-Hydroxy-5-benzyloxyacetophenone
- Packaging
- 2g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 279344
- Product name
- 2-Hydroxy-5-benzyloxyacetophenone
- Packaging
- 500mg
- Price
- $410
- Updated
- 2021/12/16
- Product number
- H829870
- Product name
- 2-Hydroxy-5-benzyloxyacetophenone
- Packaging
- 10g
- Price
- $755
- Updated
- 2021/12/16
- Product number
- 2620-1-63
- Product name
- 1-(5-(Benzyloxy)-2-hydroxyphenyl)ethanone
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
2-HYDROXY-5-BENZYLOXYACETOPHENONE Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
2-Hydroxy-5-benzyloxyacetophenone (cas# 30992-63-3) is a compound useful in organic synthesis.
Preparation
Preparation by reaction of benzyl chloride with quinacetophenone in refluxing acetone in the presence of potassium carbonate,
with potassium iodide (85%) ;
without potassium iodide (31%).
Synthesis
100-39-0
490-78-8
30992-63-3
The second alternative method first employs benzyl groups to protect the hydroxyl functional group in 2,5-dihydroxyacetophenone, followed by an O-alkylation reaction under the same conditions to give acetophenone derivatives (1-6) in high yields (95%). Next, the acetophenone derivatives (1-6) were converted by the Vilsmeier-Haack reaction under standard conditions (70% yield) to the products (1-7) which were previously synthesized by other methods. Finally, the product (1-7) was subjected to Knoevenagel condensation reaction with diethyl malonate to give the target diester (1-8) in high yield (94%). Based on the analysis of the results of Scheme 2, it can be observed that both methods can be used for the synthesis of intermediates (1-7) from 2,5-dihydroxyacetophenone (1-4) in overall yields of 42% and 66%, respectively. However, the second method showed superior performance in terms of yield.
References
[1] Patent: WO2018/156459, 2018, A1. Location in patent: Page/Page column 22; 23
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 1, p. 249 - 266
[3] Patent: US2007/88160, 2007, A1. Location in patent: Page/Page column 10-11
[4] Patent: US2010/22770, 2010, A1. Location in patent: Page/Page column 5-6
[5] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1410 - 1414
2-HYDROXY-5-BENZYLOXYACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
2-HYDROXY-5-BENZYLOXYACETOPHENONE Suppliers
View Lastest Price from 2-HYDROXY-5-BENZYLOXYACETOPHENONE manufacturers
- Product
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE 30992-63-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-05-20
- Product
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE 30992-63-3
- Price
- US $200.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20tons
- Release date
- 2024-05-22
- Product
- 2-HYDROXY-5-BENZYLOXYACETOPHENONE 30992-63-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-29