ChemicalBook > CAS DataBase List > 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID

Product Name: 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
CAS No.: 1135-23-5
Chemical Name: 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
Synonyms: 3-(4-HYDROXY-3-METHOXYPHENYL)PROPANOIC ACID;HYDROFERULIC ACID;Shorbic Acid;Dihydroconiferylic Acid;HYDROFERULIC ACID(RG);3-Methoxyphloretic Acid;Ferulic Acid Impurity 1;3-(4-HYDROXYMETHYL)PROPIONIC ACID;Dihydroferulic acid, 10 mM in DMSO;Pyridoxal 5'-phosphate hydrate(1:x)
CBNumber: CB7665965
Molecular Formula: C10H12O4
Formula Weight: 196.2
MOL File: 1135-23-5.mol

Less

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Property

Melting point:: 87-93 °C
Boiling point:: 120-130 °C(Press: 0.5 Torr)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in dimethyl sulfoxide and methanol.
pka: 4.73±0.10(Predicted)
form: powder to crystal
color: White to Light yellow
BRN: 2110370
InChI: InChI=1S/C10H12O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2,4,6,11H,3,5H2,1H3,(H,12,13)
InChIKey: BOLQJTPHPSDZHR-UHFFFAOYSA-N
SMILES: C1(CCC(O)=O)=CC=C(O)C(OC)=C1
LogP: 0.810 (est)
CAS DataBase Reference: 1135-23-5(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 2
HazardClass: IRRITANT
HS Code: 29189900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 17803
Product name: 3-(4-Hydroxy-3-methoxyphenyl)propionic acid
Purity: ≥96.0% (T)
Packaging: 5g
Price: $219
Updated: 2025/07/31

TCI Chemical

Product number: H1180
Product name: 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid
Purity: >98.0%(GC)
Packaging: 1g
Price: $81
Updated: 2025/07/31

TCI Chemical

Product number: H1180
Product name: 3-(4-Hydroxy-3-methoxyphenyl)propionic Acid
Purity: >98.0%(GC)
Packaging: 5g
Price: $199
Updated: 2025/07/31

TRC

Product number: D448900
Product name: DihydroFerulicAcid
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: OR925053
Product name: 4-Hydroxy-3-methoxy-benzenepropanoic acid
Packaging: 1g
Price: $131
Updated: 2021/12/16

Less

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Chemical Properties,Usage,Production

Uses

3-(4-Hydroxy-3-methoxyphenyl)propionic acid (hydroferulic acid) was used to inhibit prostaglandin E(2) production.

Uses

A caffeine metabolite which showed high antioxidant activity. It is a very sensitive biomarker for the consumption of relatively small amount of coffee.

Definition

ChEBI: A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 3 has been replaced by a 4-hydroxy-3-methoxyphenyl group.

Synthesis

1135-24-6

1135-23-5

The general procedure for the synthesis of isopropyl phosphate (mono- and di-ester mixtures) from 3-methoxy-4-hydroxyphenylacrylic acid was as follows: to a stirred suspension of ferulic acid (25 g, 128.74 mmol) in methanol (200 ml) was added Pd/C catalyst (3.75 g). The reaction mixture was subjected to hydrogenation under hydrogen pressure of 1.2 MPa for 4 h at 50°C. Upon completion of the reaction, the mixture was cooled to room temperature, the catalyst was removed by filtration, and a white solid product (25 g, 99% yield) was obtained by concentration under reduced pressure. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and ESI-MS: 1H NMR δ 6.76 (d, J = 7.8 Hz, 1H), 6.62 (m, 2H), 3.79 (s, 3H), 2.81 (t, J = 7.7 Hz, 2H), 2.58 (t, J = 7.7 Hz, 2H); ESI-MS m /z: 195.1 [M-H]?

in vivo

Assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food intake, respectively. Results showed that the abundance of hippuric acid and Dihydroferulic acid in HI-RS-WG rats was explained by the stronger gut microbiota fermentation in those rats than in LOW-RS-WG rats^[4].

References

[1] Advanced Synthesis and Catalysis, 2013, vol. 355, # 1, p. 81 - 86
[2] Tetrahedron Letters, 2010, vol. 51, # 44, p. 5753 - 5756
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 13, p. 4462 - 4466
[4] European Journal of Medicinal Chemistry, 2014, vol. 87, p. 429 - 439
[5] Journal of the American Chemical Society, 2017, vol. 139, # 10, p. 3767 - 3773

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID Suppliers

Americas 1 Canada 1 China 125 Europe 1 Germany 2 India 6 Japan 1 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 9 United States 21 Global 170

Shanghai ChuangYan Chemical Technology Co., Ltd.

Tel: 021-11111111 11111111111
Fax: qq:546919421
Email: 546919421@qq.com
Country: China
ProdList: 3522
Advantage: 55

LEADMEDPHARM CO.,LTD

Tel: 13674959855 13674959855
Email: sales@synthontech.com
Country: China
ProdList: 530
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangzhou Jhd Chemical Reagent Co., Ltd.

Tel: 020-84383047
Fax: 020-84380294
Email: sales@jhd.com.cn
Country: China
ProdList: 9186
Advantage: 65

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-028-85370565-229-229 18080489829
Email: 18080489829@163.com
Country: China
ProdList: 8250
Advantage: 60

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9749
Advantage: 58

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Shanghai Standard Technology Co.,Ltd.

Tel: 021-021-57127007-6622-6622 17621252073
Fax: +86 (21) 5132-0077
Email: luzh@nature-standard.com
Country: China
ProdList: 3021
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Shanghai QiQiao Biological Technology Co., Ltd.

Tel: 021-37653318; 15221675714
Email: 515366396@qq.com
Country: China
ProdList: 2089
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Suzhou XiBoli Biotechnology Co., Ltd.

Tel: 17326194005
Email: 1873444526@qq.com
Country: China
ProdList: 496
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Tianjin and Sinde Biotechnology Co., Ltd.

Tel: 15022315965; 18502259037
Email: sales_hxd@163.com
Country: China
ProdList: 509
Advantage: 58

Shanghai Standard Technology Co., Ltd.

Tel: 18502101150
Fax: +86-21-57127007-6606
Email: ft-sales@nature-standard.com
Country: CHINA
ProdList: 1923
Advantage: 58

Less

View Lastest Price from 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(4-Hydroxy-3-Methoxyphenyl)propionic acid 135-23-5
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50 tons
Release date: 2020-01-20

Shanghai Standard Technology Co., Ltd.

Product: 3-(4-Hydroxy-3-Methoxyphenyl)Propionic Acid 1135-23-5
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-25

1135-23-5, 3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACIDRelated Search:

Hexacosyl (E)-ferulate 4-HYDROXY-3-METHOXY-5-METHYLBENZENECARBALDEHYDE 2-Propenoic acid, 3-[4-(acetyloxy)-3-methoxyphenyl]-, 2-acetyl-5-methoxyphenyl ester (E)-3-(3-Hydroxy-4-methoxyphenyl)-2-propenoic acid ethyl ester 3-Feruloyl-1-Sinapoyl sucrose Methyl 3-(4-Hydroxy-3-methoxyphenyl)propionate Isopropyl ferulate CINNAMYLISOFERULATE 4-hydroxy-5-methoxyisophthalaldehyde SODIUM ISOFERULATE No Coniferyl alcohol 3-(4-HYDROXY-3,5-DIMETHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER CIS-FERULICACID 3-(4-HYDROXY-3-METHOXY-PHENYL)-2-METHYL-ACRYLIC ACID trans-4-Acetoxy-3-methoxycinnamic acid Ferulic Acid Impurity 19 N-(4-AMINOBUTYL)-3-(4-HYDROXY-3-METHOXYPHENYL)ACRYLAMIDE

3-(3-METHOXY-4-HYDROXYPHENYL)-PROPIONIC ACID

Benzenepropanoic acid, 4-hydroxy-3-methoxy-

3-Methoxyphloretic Acid

Dihydroconiferylic Acid

Shorbic Acid

β-3-Methoxy-4-hydroxyphenylpropionic acid

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID 98%

3-(4-Hydroxy-3-methoxyphenyl)propionic acid >=96.0% (T)

4-HYDROXY-3-METHOXYHYDROCINNAMIC ACID

3-METHOXY-4-HYDROXYHYDROCINNAMIC ACID

3-(4-HYDROXYMETHYL)PROPIONIC ACID

3-(4-HYDROXY-3-METHOXYPHENYL)PROPANOIC ACID

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID

BETA-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID

HYDROFERULIC ACID

3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC

HYDROFERULIC ACID(RG)

3-Methoxy-4-hydroxybenzenepropanoic acid

3-Methoxy-4-hydroxybenzenepropionic acid

4-Hydroxy-3-methoxybenzenepropanoic acid

3-(4-hydroxy-3-methoxyphenyl)propanoate

3-(4-Hydroxy-3-methoxyphenyl)propionicAcid&gt

Ferulic Acid Impurity 1

Pyridoxal 5'-phosphate hydrate(1:x)

3-(4-Hydroxy-3-methoxyphenyl)propionic Acid, ≥ 96.0%

Dihydroferulic acid, 10 mM in DMSO

1135-23-5

135-23-5

HOCH3OC6H3CH2CH2CO

Organic Building Blocks

Building Blocks

Carboxylic Acids

C10

Carbonyl Compounds

standard material,plant extracts

Inhibitors

Aromatics, Metabolites & Impurities

Aromatic Cinnamic Acids, Esters and Derivatives

Aromatics

Metabolites & Impurities