ROLITETRACYCLINE
- Product Name
- ROLITETRACYCLINE
- CAS No.
- 751-97-3
- Chemical Name
- ROLITETRACYCLINE
- Synonyms
- prm-tc;reverin;sq15,659;bristacin;syntetrex;syntetrin;Syntodecin;Tetraverin;superciclin;synotodecin
- CBNumber
- CB7666669
- Molecular Formula
- C27H33N3O8
- Formula Weight
- 527.57
- MOL File
- 751-97-3.mol
ROLITETRACYCLINE Property
- Melting point:
- 163.5°C
- Boiling point:
- 608.16°C (rough estimate)
- Density
- 1.2902 (rough estimate)
- refractive index
- 1.7120 (estimate)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- pKa 7.4 (Uncertain)
- color
- Very Dark Red to Very Dark Brown
- Water Solubility
- >20g/L(21 ºC)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 1
- RTECS
- QI9150000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 23479
- Product name
- Rolitetracycline
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 23479
- Product name
- Rolitetracycline
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $423
- Updated
- 2024/03/01
- Product number
- R640030
- Product name
- Rolitetracycline(TechnicalGrade)
- Packaging
- 25mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- R640030
- Product name
- Rolitetracycline(TechnicalGrade)
- Packaging
- 5mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CS-0007350
- Product name
- Rolitetracycline
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
ROLITETRACYCLINE Chemical Properties,Usage,Production
Description
Rolitetracycline was synthesized in 1958. Bristol-Myers Laboratories prepared it from tetracycline by introducing a pyrrolidinylmethyl moiety. This antibiotic is very soluble in water and more stable than tetracycline under acidic conditions. Rolitetracycline is used by intravenous injection, and its nitrate is used by both intravenous and intramuscular injections for therapy of the same infections as those treated by tetracycline.
Uses
Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in which the pyrrolidine moiety improves bioavailability compared with tetracycline. Rolitetracycline has broad spectrum Gram positive activity in vivo, but pH instability limits use to parenteral administration. The intrinsic in vitro activity and SARs for this region of the tetracycline molecule have not been extensively investigated.
Uses
neuromuscular blocker
Uses
Rolitetracycline is a tetracycline antibiotic that may be given intravenously or intramuscularly in serious bacterial infections when oral administration is not practicable.
Definition
ChEBI: A derivative of tetracycline in which the amide function is substituted with a pyrrolidinomethyl group.
brand name
Syntetrin (Bristol-Myers Squibb).
General Description
Rolitetracycline, N-(pyrrolidinomethyl)tetracycline(Syntetrin), was introduced for use by intramuscular or intravenousinjection. This derivative is made by condensingtetracycline with pyrrolidine and formaldehyde in the presenceof tert-butyl alcohol. It is very soluble in water (1 g dissolvesin about 1 mL) and provides a means of injecting theantibiotic in a small volume of solution. It has been recommendedfor cases when the oral dosage forms are not suitable,but it is no longer widely used.
Pharmaceutical Applications
2-N-pyrrolidinomethyl-tetracycline. A semisynthetic derivative
of tetracycline supplied as the nitrate sesquihydrate for
parenteral use.
It is not absorbed from the gastrointestinal tract. It is highly
soluble and therefore can be administered parenterally. Peak
plasma concentrations of 4–6 mg/L occur at 0.5–1 h after
350 mg intravenously. The plasma elimination half-life is 5–8 h.
About 50% of the dose is excreted in the urine, producing
high concentrations.
Intravenous administration is occasionally accompanied by
abnormal taste, shivering and rigors, hot flushes, facial reddening,
dizziness and, rarely, circulatory collapse. Symptoms
of myasthenia gravis have occasionally been exacerbated.
ROLITETRACYCLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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