ChemicalBook > CAS DataBase List > BOC-L-3-BENZOTHIENYLALANINE

BOC-L-3-BENZOTHIENYLALANINE

Product Name: BOC-L-3-BENZOTHIENYLALANINE
CAS No.: 154902-51-9
Chemical Name: BOC-L-3-BENZOTHIENYLALANINE
Synonyms: BOC-L-BTA;BOC-BTA-OH;BOC-ALA(3-BZT)-OH;RARECHEM BK PT 0204;BOC-L-3-BENZOTHIENYLALA;BOC-ALA(3-BENZOTHIENYL)-OH;BOC-L-3-BENZOTHIENYLALANINE;BOC-3-BENZOTHIENYL-L-ALANINE;BOC-3-ALA(3-BENZOTHIENYL)-OH;boc-β-(3-benzothienyl)-ala-oh
CBNumber: CB7667505
Molecular Formula: C16H19NO4S
Formula Weight: 321.39
MOL File: 154902-51-9.mol

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BOC-L-3-BENZOTHIENYLALANINE Property

Boiling point:: 514.1±45.0 °C(Predicted)
Density: 1.274±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: 3.85±0.10(Predicted)
Appearance: White to off-white Solid
BRN: 7081201
CAS DataBase Reference: 154902-51-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
WGK Germany: 3
F: 10-23
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15040
Product name: Boc-β-(3-benzothienyl)-Ala-OH
Purity: ≥96.0% (TLC)
Packaging: 1g
Price: $53.6
Updated: 2024/03/01

TRC

Product number: B625960
Product name: Boc-L-3-benzothienylalanine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Usbiological

Product number: 235904
Product name: Boc-3-benzothienyl-L-alanine 99+%
Packaging: 1g
Price: $207
Updated: 2021/12/16

Usbiological

Product number: 264862
Product name: Boc-3-benzothienyl-L-alanine
Packaging: 1g
Price: $360
Updated: 2021/12/16

Activate Scientific

Product number: AS88686
Product name: Boc-3-(3-Benzothienyl)-L-alanine
Purity: 95% ee
Packaging: 5G
Price: $373
Updated: 2021/12/16

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BOC-L-3-BENZOTHIENYLALANINE Chemical Properties,Usage,Production

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

72120-71-9

154902-51-9

General procedure for the synthesis of (S)-3-(benzo[b]thiophen-3-yl)-2-((tert-butoxycarbonyl)amino)propionic acid from di-tert-butyl dicarbonate and (S)-2-amino-3-(benz[b]thiophen-3-yl)propionic acid: to a THF:H2O (1.0 g, 4.52 mmol) solution containing K2CO3 (0.75 g, 5.33 mmol) and (S)-2-amino-3-(benzo[b]thieno -3-yl)propionic acid (1.0 g, 4.52 mmol) to a solution of THF:H2O (1:1, v/v) was slowly added di-tert-butyl dicarbonate (1.09 g, 5 mmol). Subsequently, the reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, the mixture was concentrated to remove most of the solvent and then the residue was dissolved in a mixture of EtOAc and H2O. The pH of the aqueous phase was adjusted to 1-2 with 6N HCl, followed by three extractions with EtOAc. The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated to give 1.22 g of the target product as a white foamy solid in 84% yield.

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099
[2] Patent: WO2005/85227, 2005, A1. Location in patent: Page/Page column 47; 117

BOC-L-3-BENZOTHIENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-3-BENZOTHIENYLALANINE Suppliers

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154902-51-9, BOC-L-3-BENZOTHIENYLALANINERelated Search:

BOC-L-2-AMINOMETHYLPHE(FMOC) Thianaphthene BOC-D-3-BENZOTHIENYLALANINE L-3-THIENYLALANINE BOC-L-3-BENZOTHIENYLALANINE 3-THIEN-3-YLPROPANOIC ACID 3-(3-benzo(b)thienyl)alanine BOC-(S)-ALPHA-(3-BENZOTHIOPHENYLMETHYL)-PROLINE BOC-L-3-THIENYLALANINE DCHA SALT BOC-3-(3-BENZOTHIENYL)-DL-ALANINE 3-THIOPHENEPROPIONIC ACID L-3-BENZOTHIENYLALANINE (2-THIOPHEN-3-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER BOC-DL-3-THIENYLALANINE 3-(Benzo[b]thiophen-3-yl)propanoicacid

RARECHEM BK PT 0204

N-ALPHA-T-BOC-BETA-(3-BENZOTHIENYL)-L-ALANINE

N-ALPHA-T-BUTOXYCARBONYL-3-(3-BENZOTHIENYL)-L-ALANINE

BOC-3-(3-BENZOTHIENYL)-L-ALANINE

BOC-L-3-BENZOTHIENYLALA

BOC-L-3-BENZOTHIENYLALANINE

BOC-L-3-(3-BENZOTHIENYL)ALANINE

BOC-BTA-OH

BOC-ALA(3-BENZOTHIENYL)-OH

BOC-ALA(3-BZT)-OH

BOC-3-BENZOTHIENYL-L-ALANINE

BOC-3-ALA(3-BENZOTHIENYL)-OH

BOC-ALA-BETA-(3-BENZOTHIENYL)-OH

BOC-BETA-(3-BENZOTHIENYL)-L-ALANINE

BOC-BETA-(3-BENZOTHIENYL)-ALANINE

BOC-BETA-(3-BENZOTHIENYL)-ALA-OH

boc-β-(3-benzothienyl)-ala-oh

3-Benzo[b]thiophen-3-yl-L-alanine, N-BOC protected

(S)-3-(benzo[b]thiophen-3-yl)-2-(tert-butoxycarbonylamino)propanoic acid

NALPHA-tert-Butoxycarbonyl-3-(3-benzothienyl)-L-alanine

(2S)-3-(3-benzylthiophen-2-yl)-2-{[(tert-butoxy)carbonyl]aMino}propanoic acid

Boc-b-(3-benzothienyl)-Ala-OH

3-(1-benzothien-3-yl)-N-{[(1,1-diMethylethyl)oxy]carbonyl}-L-alanine

BOC-L-BTA

Boc-3-benzothienyl-L-alanine99%

Boc-3-L-Ala(3-benzothienyl)-OH

(Tert-Butoxy)Carbonyl L-3-Benzothienylalanine

N-Boc-S-(Benzothien-3-yl)-alanine

N-BOC-L-3-Benzothienylalanine

Boc-β-(3-benzothienyl)-L-Ala-OH

(2S)-3-(1-benzothiophen-3-yl)-2-{[(tert-butoxy)carbonyl]amino}propanoic acid

(2S)-3-(1-benzothiophen-3-yl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid

(αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzo[b]thiophene-3-propanoic acid

Benzo[b]thiophene-3-propanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αS)-

Boc-β-(3-benzothienyl)-Ala-OH, CAS 154902-51-9

N-BOC-L-3-Benzothiophene Alanine

154902-51-9

157902-51-9

C16H19NO4S

Alanine Derivatives

Unnatural Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Phenylalanine analogs and other aromatic alpha amino acids

Amino Acids

Amino Acid Derivatives

a-amino