2-Amino-6-methyl-4-pyrimidinol

Application

Product Name: 2-Amino-6-methyl-4-pyrimidinol
CAS No.: 3977-29-5
Chemical Name: 2-Amino-6-methyl-4-pyrimidinol
Synonyms: 2-AMINO-4-HYDROXY-6-METHYLPYRIMIDINE;6-METHYLISOCYTOSINE;2-Amino-6-methylpyrimidin-4(1H)-one;2-AMINO-6-METHYLPYRIMIDIN-4-OL;6-aMino-2-MethylpyriMidin-4-ol;AHLP;1n-22636;1n-10718;Superacil;Superacyl
CBNumber: CB7669802
Molecular Formula: C5H7N3O
Formula Weight: 125.13
MOL File: 3977-29-5.mol

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2-Amino-6-methyl-4-pyrimidinol Property

Melting point:: >300 °C (lit.)
Boiling point:: 232.57°C (rough estimate)
Density: 1.2602 (rough estimate)
refractive index: 1.6190 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Aqueous Base (Sparingly), DMSO (Slightly)
form: Powder
pka: 10.03±0.50(Predicted)
color: White to cream
BRN: 3531
InChI: InChI=1S/C5H7N3O/c1-3-2-4(9)8-5(6)7-3/h2H,1H3,(H3,6,7,8,9)
InChIKey: KWXIPEYKZKIAKR-UHFFFAOYSA-N
SMILES: C1(N)=NC(C)=CC(=O)N1
CAS DataBase Reference: 3977-29-5(CAS DataBase Reference)
NIST Chemistry Reference: Pyrimidine, 2-amino-4-hydroxy-6-methyl- (keto form)(3977-29-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36/37/39-26-22
WGK Germany: 3
RTECS: UW7362250
HazardClass: IRRITANT
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A58003
Product name: 2-Amino-4-hydroxy-6-methylpyrimidine
Purity: 98%
Packaging: 25g
Price: $56.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: A58003
Product name: 2-Amino-4-hydroxy-6-methylpyrimidine
Purity: 98%
Packaging: 100g
Price: $96.1
Updated: 2025/07/31

TCI Chemical

Product number: A1204
Product name: 2-Amino-4-hydroxy-6-methylpyrimidine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: A1204
Product name: 2-Amino-4-hydroxy-6-methylpyrimidine
Purity: >98.0%(HPLC)(T)
Packaging: 250g
Price: $244
Updated: 2025/07/31

TRC

Product number: A898143
Product name: 2-Amino-6-methylpyrimidin-4(3H)-one
Packaging: 1g
Price: $50
Updated: 2021/12/16

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2-Amino-6-methyl-4-pyrimidinol Chemical Properties,Usage,Production

Application

2-Amino-4-hydroxy-6-methylpyrimidine is a pyrimidine derivative that can be used as a pharmaceutical intermediate.

Chemical Properties

white powder

Definition

ChEBI: An aminopyrimidine compound having its amino group at position 2 and hydroxy and methyl substituents at positions 4 and 6 respectively.

Synthesis

141-97-9

113-00-8

3977-29-5

The general procedure for the synthesis of 2-amino-4-hydroxy-6-methylpyrimidines from ethyl acetoacetate and the compound (CAS: 113-00-8) was carried out as follows: referring to the literature method [26] with slight modifications. Guanidine (2.02 g, 33.84 mM) was dissolved in acetone/ethanol solvent mixture (1:2, v/v) and an acetone/ethanol solution of ethyl acetoacetate (4.40 g, 33.86 mM) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 10 hours. After completion of the reaction, the solid product was isolated by filtration and recrystallized from acetic acid to obtain colorless crystals. Yield: 1.36 g (52%). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3, ppm): δ 11.09 (s, 1H, OH), 5.92 (s, 2H, NH2), 5.14 (s, 1H, Ar-H), 2.14 (s, 3H, Ar-CH3).13C NMR (100 MHz, CDCl3, ppm) data: δ 162.3, 161.1, 155.3, 102.5, 23.9. ESI-MS analysis: calculated value C5H7N3O [M+] is 125.06; measured value is 126.07 [M++1].

References

[1] Polyhedron, 2017, vol. 129, p. 141 - 148

2-Amino-6-methyl-4-pyrimidinol Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium Guanidine hydrochloride Diethyl ether

Preparation Products

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2-Amino-6-methyl-4-pyrimidinol Suppliers

Americas 1 Belgium 2 China 208 Europe 3 France 1 Germany 7 India 11 Japan 3 Russia 2 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 11 United States 39 Global 295

MDP ChemControl Ltd.

Tel: --
Fax: --
Email: chemcontrol@nextra.sk
Country: Slovakia
ProdList: 6700
Advantage: 60

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View Lastest Price from 2-Amino-6-methyl-4-pyrimidinol manufacturers

Dideu Industries Group Limited

Product: 2-Amino-6-methyl-4-pyrimidinol 3977-29-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-06

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Amino-6-methyl-4-pyrimidinol 3977-29-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 2-Amino-6-methyl-4-pyrimidinol 3977-29-5
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-23

3977-29-5, 2-Amino-6-methyl-4-pyrimidinolRelated Search:

6-AMINO-2-METHYL-4-PYRIMIDINOL DIHYDRATE 2-AMINO-5-BROMO-4-HYDROXY-6-METHYLPYRIMIDINE 2-Amino-4-methoxy-6-methylpyrimidine Pirimiphos ethyl ETHIRIMOL 2-AMINO-4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE 2-Amino-6-methyl-4-pyrimidinol Pirimiphos-methyl BUPIRIMATE Pirimicarb 2-AMINO-5,6-DIMETHYL-4-HYDROXYPYRIMIDINE 2-AMINO-6-HYDROXY-PYRIMIDINE-4-CARBOXYLIC ACID 4-Amino-5-methyl-2-pyrimidinol 4-amino-2-methyl-6-pyrimidinol hydrate,6-AMINO-2-METHYL-4-PYRIMIDINOL 4-Methylpyrimidine 4-Hydroxy-6-methylpyrimidine 4-Hydroxypyrimidine 4-HYDROXY-6-METHYLPYRIMIDINE

1n-22636

2-Amino-4-hydroxy-4-methylpyrimidine

2-amino-6-methyl-4(1h)-pyrimidinon

2-AMINO-6-METHYLPYRIMIDIN-4-OL

2-AMINO-6-METHYL-4-PYRIMIDINOL

2-AMINO-4-METHYL-6-HYDROXYPYRIMIDINE

AHLP

6-METHYLISOCYTOSINE

4(1H)-Pyrimidinone, 2-amino-6-methyl- (8CI,9CI)

AMINOHYDROXYMETHYLPYRIMIDINE

2-AMINO-4-HYDROXY-6-METHYLPYRIMIDINE, 98 %

2-amino-6-methyl-4(1H)-Pyrimidinone (8CI,9CI)

2-Amino-6-methyl-4-pyrimidinol, 6-Methylisocytosine

2-Amino-4-methylpyrimidin-6-ol

2-Amino-6-methyl-1,4-dihydropyrimidine-4-one

2-Amino-6-methylpyrimidine-4(1H)-one

2-Amino-6-methylpyrimidine-4(3H)-one

2-Amino-6-hydroxy-4-methylpyrimidine

2-Amino-4-hydroxy-6-methylpyrimidine,99%

6-aMino-2-MethylpyriMidin-4-ol

2-AMino-4-hydroxy-6-MethylpyriMidine, 99% 100GR

2-AMino-4-hydroxy-6-MethylpyriMidine, 99% 25GR

2-AMino-6-Methyl-3H-pyriMidin-4-one

4-Hydroxy-2-aMino-6-MethylpyriMidine

4(3H)-PyriMidinone,2-aMino-6-Methyl-

2-AMino-4-hydroxy-6-MethylpyriMidine 98%

2-Amino-4-hydroxy-6-methyL

2-amino-6-methyl-4(1h)-pyrimidinone

2-amino-6-methyl-4-pyrimidino

2-AMINO-4-HYDROXY-6-METHYLPYRIMIDINE

1n-10718

4(1H)-Pyrimidinone, 2-amino-6-methyl-

4-Methylisocytosine

Mecytosine

n.b.e-43094-20

Superacil

Superacyl

2-Amino-6-methylpyrimidin-4(1H)-one

2-Amino-6-methyl-1,4-dihydropyrimidin-4-one

2-Amino-4-hydroxy-6-methylpyrimidine &gt

2-Amino-6-methyl-4-pyrimidinol ISO 9001：2015 REACH

2-amino-6-methyl-1H-pyrimidin-4-one

Fampridine Impurity 214

3977-29-5

Building Blocks

Heterocyclic Building Blocks

Pyrimidines

Heterocycle-Pyrimidine series

PYRIMIDINE

Fluorobenzene

Amines

Pyrimidines