5-Chloro-1H-indazole-3-carboxylic acid
Application- Product Name
- 5-Chloro-1H-indazole-3-carboxylic acid
- CAS No.
- 1077-95-8
- Chemical Name
- 5-Chloro-1H-indazole-3-carboxylic acid
- Synonyms
- 5-CHLORO-3-INDAZOLECARBOXYLIC ACID;5-CHLORO-3-INDOZOLE-CARBOXYLIC ACID;5-chloro-1H-indazol-3-carboxylic acid;5-chloro-1h-indazole-3-carboxylic acod;5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID;5-CHLORO-3-(1H)INDAZOLE CARBOXYLIC ACID;1H-Indazole-3-carboxylic acid, 5-chloro-;5-Chloro-1H-indazole-3-carboxylic acid ,97%
- CBNumber
- CB7675256
- Molecular Formula
- C8H5ClN2O2
- Formula Weight
- 196.59
- MOL File
- 1077-95-8.mol
5-Chloro-1H-indazole-3-carboxylic acid Property
- Melting point:
- 337 °C
- Boiling point:
- 472.1±25.0 °C(Predicted)
- Density
- 1.644±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 2.82±0.30(Predicted)
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C421903
- Product name
- 5-Chloro-1h-indazole-3-carboxylicacid
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- OR912768
- Product name
- 5-Chloro-1H-indazole-3-carboxylicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- OR912768
- Product name
- 5-Chloro-1H-indazole-3-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC35231
- Product name
- 5-chloro-1h-indazole-3-carboxylic acod
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Y6984
- Product name
- 5-Chloro-1H-indazole-3-carboxylicacid
- Packaging
- 1g
- Price
- $171
- Updated
- 2021/12/16
5-Chloro-1H-indazole-3-carboxylic acid Chemical Properties,Usage,Production
Application
5-Chloro-1H-indazole-3-carboxylic acid is an important pharmaceutical intermediate used to construct the core of active drug molecules.
Chemical Properties
Light yellow solid
Synthesis
1H-indazole-3-carboxylic acid was dissolved in anhydrous acetic acid in a three-necked flask, heated and stirred. After the substrate was dissolved and clarified, phosphorus oxychloride was dissolved in anhydrous acetic acid and slowly added dropwise. In an oil bath at 90°C, the mixture was condensed back into the chemical book and reacted for 14 hours. After the reaction was complete, a white precipitate was produced. It was cooled in an ice bath, vacuum filtered, and the solid was washed with ethyl acetate first and then with ether to obtain 5-Chloro-1H-indazole-3-carboxylic acid.
References
[1] Patent: WO2005/14554, 2005, A1. Location in patent: Page/Page column 60-61
[2] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0356
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6259 - 6272
[4] Patent: WO2015/103317, 2015, A1. Location in patent: Page/Page column 97
5-Chloro-1H-indazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-1H-indazole-3-carboxylic acid Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 3993
- Advantage
- 55
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 021-54849683 13601642561
- Fax
- +86-21-54375689
- sales@keepontech.com
- Country
- China
- ProdList
- 998
- Advantage
- 59
- Tel
- +86 (21) 6715-7650
- Fax
- +86 (21) 6715-7651
- sheepchem@163.com
- Country
- China
- ProdList
- 994
- Advantage
- 60
- Tel
- 18171398856 2968382473
- Fax
- 0086-21-50758330
- service@runpharm.com
- Country
- China
- ProdList
- 716
- Advantage
- 55
View Lastest Price from 5-Chloro-1H-indazole-3-carboxylic acid manufacturers
- Product
- 5-CHLORO-1H-INDAZOLE-3-CARBOXYLIC ACID 1077-95-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2019-08-05