ChemicalBook > CAS DataBase List > 1-(4-Fluorobenzyl)-2-chlorobenzimidazole

1-(4-Fluorobenzyl)-2-chlorobenzimidazole

Product Name
1-(4-Fluorobenzyl)-2-chlorobenzimidazole
CAS No.
84946-20-3
Chemical Name
1-(4-Fluorobenzyl)-2-chlorobenzimidazole
Synonyms
1-(4-Fluorobenzyl)-2;Mizolastine Impurity 19;1-(4-Fluorobenzyl)-2-Chloro-Be;N-METHYL-N-(-CHLOROETHYL) ANILINE;3-(4'-FLUOROBENZY)-2-CHLOROBENZIMIDAZOLE;2-CHLORO-1-(4-FLUOROBENZYL)BENZIMIDAZOLE;1-(4-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOL&;1-(4-Flourobenzyl)-2-chlorobenzimidazole;3-(4-Fluorobenzyl)-2-Chlorobenzimidazole;1-(4-FLUOROBENZYL)-2-CHLORO-BENZIMIDAZOLE
CBNumber
CB7692741
Molecular Formula
C14H10ClFN2
Formula Weight
260.69
MOL File
84946-20-3.mol
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1-(4-Fluorobenzyl)-2-chlorobenzimidazole Property

Melting point:
83-87 °C(lit.)
Boiling point:
432.3±47.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
3.42±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C14H10ClFN2/c15-14-17-12-3-1-2-4-13(12)18(14)9-10-5-7-11(16)8-6-10/h1-8H,9H2
InChIKey
PGXALMVNIRPELS-UHFFFAOYSA-N
SMILES
C1(Cl)N(CC2=CC=C(F)C=C2)C2=CC=CC=C2N=1
CAS DataBase Reference
84946-20-3(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2850
Product name
2-Chloro-1-(4-fluorobenzyl)benzimidazole
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
C2850
Product name
2-Chloro-1-(4-fluorobenzyl)benzimidazole
Purity
>98.0%(GC)
Packaging
25g
Price
$189
Updated
2024/03/01
Matrix Scientific
Product number
090839
Product name
2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
Purity
95+%
Packaging
5g
Price
$252
Updated
2021/12/16
Matrix Scientific
Product number
090839
Product name
2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
Purity
95+%
Packaging
10g
Price
$378
Updated
2021/12/16
AK Scientific
Product number
I087
Product name
1-(4-Fluorobenzyl)-2-chloro-benzimidazole
Packaging
1g
Price
$21.68
Updated
2021/12/16
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1-(4-Fluorobenzyl)-2-chlorobenzimidazole Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A novel aldose reductase (ALR2) inhibitor.

Synthesis

4857-06-1

459-46-1

84946-20-3

General procedure for the synthesis of 1-(4-fluorobenzyl)-2-chlorobenzimidazole from 2-chlorobenzimidazole and 4-fluorobenzyl bromide: To a solution of 2-chlorobenzimidazole (5 g, 32.7 mmol) in acetonitrile (30 ml) was added potassium hydroxide (2.62 g, 46.6 mmol). The mixture was heated to 80°C and stirred for 30 minutes until the solution was clarified. After cooling to room temperature, 4-fluorobenzyl bromide (9.29 g, 49.1 mmol) was added and the reaction was refluxed at 80 °C for 5 h. The reaction solution appeared white and turbid. After completion of the reaction, the reaction solution was extracted with dichloromethane (100 mL x 3) three times, the organic layers were combined, washed with distilled water and dried with anhydrous magnesium sulfate. After filtration, the organic phase was concentrated to give a white solid. It was recrystallized by acetone/petroleum ether mixed solvent, cooled, filtered and dried to obtain a white solid product in 91.1% yield.

References

[1] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 3, p. 245 - 249
[2] Patent: CN104910894, 2017, B. Location in patent: Paragraph 0032; 0034; 0036; 0037; 0055
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6291 - 6294
[4] Heterocycles, 1999, vol. 51, # 11, p. 2561 - 2573
[5] Patent: US5922737, 1999, A

1-(4-Fluorobenzyl)-2-chlorobenzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Fluorobenzyl)-2-chlorobenzimidazole Suppliers

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View Lastest Price from 1-(4-Fluorobenzyl)-2-chlorobenzimidazole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
1-(4-Fluorobenzyl)-2-chlorobenzimidazole 84946-20-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-13
Career Henan Chemical Co
Product
1-(4-Fluorobenzyl)-2-chlorobenzimidazole 84946-20-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-08-08

84946-20-3, 1-(4-Fluorobenzyl)-2-chlorobenzimidazoleRelated Search:

2-Chlorobenzimidazole Methyl salicylate Benzyl chloride 2-Chloromethylbenzimidazole Methyl acrylate Methanol Methylparaben Kresoxim-methyl Benzyl chloromethyl ether Benzimidazole METSULFURON METHYL Basic Violet 1 Tribenuron methyl Mizolastine Impurity 8 Mizolastine Impurity 3 Acetate Mizolastine Impurity 9 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine Mizolastine Impurity 5

  • 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]iMidazole
  • 2-Chloro-1-(4-fluorobenzyl)benzimidazole 97%
  • N-METHYL-N-(-CHLOROETHYL) ANILINE
  • 3-(4'-FLUOROBENZY)-2-CHLOROBENZIMIDAZOLE
  • 1-(4'-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOLE
  • 1-(4-FLUOROBENZYL)-2-CHLORO-BENZIMIDAZOLE
  • 1-(4-FLUOROPHENYLMETHYL)-2-CHLOROBENZIMIDAZOLE
  • 2-CHLORO-1-(4-FLUOROBENZYL)-1H-BENZIMIDAZOLE
  • 2-CHLORO-1-(4-FLUOROBENZYL)BENZIMIDAZOLE
  • 2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole
  • 2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole(CFMB)
  • 1-(4-FLUOROBENZYL)-2-CHLOROBENZIMIDAZOL&
  • 1-(4-Flourobenzyl)-2-chlorobenzimidazole
  • 1-(4-Fluorobenzyl)-2-Chloro-Be
  • 1-(4-fluorobenzyl)-2-chlorobenzimidazole (intermediate of mizolastine)
  • 1-(4-Fluorobenzyl)-2-chlorobenzimidazole 2-Chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole
  • 1-(4-fluorobenzyl)-2-chloro-1H-benzo[d]imidazole
  • 1-(4-Fluorobenzyl)-2-chlorobenzimidazole, 2-Chloro-1-(4-fluorobenzyl)-1H-benzimidazole
  • 1-(4-Fluorobenzyl)-2
  • 1-(4-Fluorobenzyl)-2-chlorobenzimidazole 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]iMidazole
  • 3-(4-Fluorobenzyl)-2-Chlorobenzimidazole
  • 2-chloro-1-[(4-fluorophenyl)methyl]benzimidazole
  • 2-Chloro-1-(4-fluorobenzyl)benzimidazole &gt
  • 1H-Benzimidazole, 2-chloro-1-[(4-fluorophenyl)methyl]-
  • Mizolastine Impurity 19
  • 2-Chloro-1-(4-fluorobenzyl)benzimidazole, ≥ 98.0%
  • 2-Chloro-1-(4-fluorobenzyl)benzimidazole, 10 mM in DMSO
  • 84946-20-3
  • C14H10ClFN2
  • Benzimidazoles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Heterocycles
  • PHARMACEUTICAL INTERMEDIATES
  • Imidazol&Benzimidazole
  • (intermediate of mizolastine)