EA4
- Product Name
- EA4
- CAS No.
- 389614-94-2
- Chemical Name
- EA4
- Synonyms
- EA4;7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione;5,8-Quinolinedione, 7-chloro-6-[4-(diethylamino)phenyl]-
- CBNumber
- CB7697201
- Molecular Formula
- C19H17ClN2O2
- Formula Weight
- 340.8
- MOL File
- 389614-94-2.mol
EA4 Property
- Boiling point:
- 508.3±50.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- -196°C
- solubility
- ≤1mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 6.14±0.44(Predicted)
- color
- Light blue to blue
N-Bromosuccinimide Price
- Product number
- CB_96073116
- Product name
- Ea.4
- Purity
- NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.
- Packaging
- 1 unit
- Price
- $402
- Updated
- 2025/07/31
- Product number
- CB_96073116
- Product name
- Ea.4
- Purity
- NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose
- Packaging
- 1 unit
- Price
- $402
- Updated
- 2025/07/31
- Product number
- CB_96073116
- Product name
- Ea.4
- Purity
- 96073116
- Packaging
- 1VIAL
- Price
- $981
- Updated
- 2025/07/31
- Product number
- CB_96073116
- Product name
- Ea.4
- Purity
- 96073116
- Packaging
- 96073116-DNA-5UG
- Price
- $390
- Updated
- 2024/03/01
- Product number
- 10111
- Product name
- EA4
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
EA4 Chemical Properties,Usage,Production
Uses
EA4, a derivative of quinone, is an inhibitor for both rPLA and cPLA. EA4 can inhibit rPLA2 with a Ki value of 130 μM. EA4 can be used for the research of hemostasis, thrombosis, and erythropoiesis[1].
Biological Activity
ki: 130 μmea4 is a rpla2 inhibitor.rpla2, a calcium-dependent cytosolic phospholipase a2 (cpla2), was initially isolated and characterized from bovine and human red blood cells. with a molecular mass of 42 kda, cpla2 shows biochemical properties similar to cpla2 type iv.
in vitro
it was found that ea4 was able to inhibit a ca(2+) ionophore-induced arachidonic acid release from both human and bovine red blood cells, demonstrating that this enzyme was responsible for the ca(2+)-dependent arachidonic acid release from mammalian red blood cells [1]. another study found that in mouse hepatoma hepa-1c1c7 cells, ea4 could cause a significant induction of the cyp1a1-mediated ethoxyresorufin o-deethylase activity time- and concentration-dependently, and such induction was accompanied by an increase of the cyp1a1 mrna transcription. morevoer, in human cells including mcf-7 (human breast adenocarcinoma cell line), hepg2 (human hepatocarcinoma), and hl-60 (human promyelocytic cell line), the expression of cyp1a1 mrna could be also induced by ea4 treatment. in addition, cyp1b1 mrna was increased by ea4 in mcf-7 cells [2].
References
1. shin, h.s.,chin, m.r.,kim, j.s., et al. purification and characterization of a cytosolic, 42-kda and ca2+-dependent phospholipase a2 from bovine red blood cells. the journal of biological chemisty 277, 21086-21094 (2002).2. chun, y.j.,lee, b.y.,yang, s.a., et al. induction of cytochrome p450 1a1 gene expression by a vitamin k3 analog in mouse hepatoma hepa-1c1c7 cells. molecules and cells 12, 190-196 (2001).
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