2-(TETRAHYDROFURAN-2-YL)ACETONITRILE
- Product Name
- 2-(TETRAHYDROFURAN-2-YL)ACETONITRILE
- CAS No.
- 33414-62-9
- Chemical Name
- 2-(TETRAHYDROFURAN-2-YL)ACETONITRILE
- Synonyms
- 2-(oxolan-2-yl)acetonitrile;Tetrahydrofurfurylcarbonitrile;2-(Cyanomethyl)tetrahydrofuran;tetrahydro-2-furylacetonitrile;2-Furanacetonitrile, tetrahydro-;TETRAHYDROFURAN-2-YLACETONITRILE;(+/-)-2-oxolan-2-ylethanenitrile;2-(TETRAHYDROFURAN-2-YL)ACETONITRILE;Tetrahydrofurfurylcarbonitrile 2-(Cyanomethyl)tetrahydrofuran
- CBNumber
- CB7702970
- Molecular Formula
- C6H9NO
- Formula Weight
- 111.14
- MOL File
- 33414-62-9.mol
2-(TETRAHYDROFURAN-2-YL)ACETONITRILE Property
- Boiling point:
- 92°C/13mmHg(lit.)
- Density
- 1.003±0.06 g/cm3(Predicted)
- refractive index
- 1.4460 to 1.4500
- form
- clear liquid
- color
- Colorless to Light yellow to Light orange
Safety
- HS Code
- 2932190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T2622
- Product name
- (Tetrahydrofuran-2-yl)acetonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $192
- Updated
- 2025/07/31
- Product number
- T795558
- Product name
- 2-(Tetrahydrofuran-2-yl)acetonitrile
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR937427
- Product name
- 2-(Tetrahydrofuran-2-yl)acetonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 42884
- Product name
- (Tetrahydrofuran-2-yl)acetonitrile,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 5G
- Price
- $206.85
- Updated
- 2021/12/16
- Product number
- OR937427
- Product name
- 2-(Tetrahydrofuran-2-yl)acetonitrile
- Purity
- 95%
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
2-(TETRAHYDROFURAN-2-YL)ACETONITRILE Chemical Properties,Usage,Production
Synthesis
773837-37-9
72641-13-5
33414-62-9
Tetrahydrofurfuryl alcohol (2.01 g, 19.7 mmol, 1.0 eq.) was dissolved in dichloromethane (100 mL) under argon protection and cooled to 0 °C. Triethylamine (3.02 mL, 21.7 mmol, 1.1 eq.) and methanesulfonyl chloride (1.60 mL, 20.7 mmol, 1.05 eq.) were added sequentially. The ice bath was removed and the reaction mixture continued to stir for 14 hours. Subsequently, the mixture was transferred to a partition funnel and water was added for phase separation. The organic phase was washed with water (4 times), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude tetrahydrofurfuryl methanesulfonate (3.26 g, 92% yield) as a light yellow oil, which was used directly in the next step of the reaction. The above crude tetrahydrofurfuryl methanesulfonate (1.0 g, 5.56 mmol, 1.0 eq.) was dissolved in DMSO (5 mL) under argon protection, and reacted with NaCN (817 mg, 16.7 mmol, 3 eq.) for 3.5 h at 80 °C. The reaction was completed by cooling to room temperature. After completion of the reaction, it was cooled to room temperature, diluted with ether and washed with saturated sodium bicarbonate solution. The aqueous phase was extracted with ether (4 times). The organic phases were combined, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure [note: the product may be volatile] to give the crude oil. Purification by fast column chromatography (20-50% ethyl acetate/hexane) gave the target product 2-(tetrahydrofuran-2-yl)acetonitrile (247 mg, 40% yield). 2-(Tetrahydrofuran-2-yl)acetonitrile (75 mg, 670 μmol, 1.0 equiv.) was reacted with BH3-THF solution (0.5 mL, 5 mmol, excess; 1.0 M in THF) under argon protection for 2 h at room temperature. The reaction solution was rotary evaporated to dryness to give a crude oil. It was carefully treated with the addition of methanol and rotary evaporated again. The residue was treated with methanol (0.5 mL) and 1.0 N aqueous hydrochloric acid (0.5 mL) overnight at room temperature and subsequently concentrated under reduced pressure. Purification by fast column chromatography (0-10% methanol/dichloromethane containing 1-2% ammonia) afforded the pure product 3-(tetrahydrofuran-2-yl)ethylamine (33 mg, 43% yield).ESI-MS (m/z) 116 [M + H]+.
References
[1] Patent: US2004/87601, 2004, A1. Location in patent: Page 27
2-(TETRAHYDROFURAN-2-YL)ACETONITRILE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-(TETRAHYDROFURAN-2-YL)ACETONITRILE manufacturers
- Product
- 2-(TETRAHYDROFURAN-2-YL)ACETONITRILE 33414-62-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-01