5-METHOXY-3,4-DIHYDRO-2H-PYRROLE
- Product Name
- 5-METHOXY-3,4-DIHYDRO-2H-PYRROLE
- CAS No.
- 5264-35-7
- Chemical Name
- 5-METHOXY-3,4-DIHYDRO-2H-PYRROLE
- Synonyms
- c-C4H6N(2-OCH3);2-methoxypyrrole;AKOS BBS-00007016;2-METHOXY-1-PYRROLINE;Tipiracil Impurity 16;Piracetam EP Impurity 5;2-Methoxy-1-pyrrolidine;4,5-Dihydro-2-methoxy-3H-pyrrole;5-METHOXY-3,4-DIHYDRO-2H-PYRROLE;3,4-dihydro-5-methoxy-2H-Pyrrole
- CBNumber
- CB7703937
- Molecular Formula
- C5H9NO
- Formula Weight
- 99.13
- MOL File
- 5264-35-7.mol
5-METHOXY-3,4-DIHYDRO-2H-PYRROLE Property
- Boiling point:
- 118-121 °C
- Density
- 1.05±0.1 g/cm3(Predicted)
- refractive index
- 1.4375
- storage temp.
- 2-8°C
- pka
- 6.29±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C5H9NO/c1-7-5-3-2-4-6-5/h2-4H2,1H3
- InChIKey
- QYGNDKJRRNVSEC-UHFFFAOYSA-N
- SMILES
- N1=C(OC)CCC1
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M323625
- Product name
- 2-Methoxy-1-pyrroline
- Packaging
- 10g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 7443AB
- Product name
- 2-Methoxy-1-pyrroline
- Packaging
- 25g
- Price
- $398
- Updated
- 2021/12/16
- Product number
- CHM0021151
- Product name
- 2-METHOXY-1-PYRROLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $765.23
- Updated
- 2021/12/16
- Product number
- CHM0021151
- Product name
- 2-METHOXY-1-PYRROLINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
- Product number
- CHM0021151
- Product name
- 2-METHOXY-1-PYRROLINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1295.03
- Updated
- 2021/12/16
5-METHOXY-3,4-DIHYDRO-2H-PYRROLE Chemical Properties,Usage,Production
Uses
2-Methoxy-1-pyrroline acts as a reagent in the design and preparation of dihydroindolones and dihydroindolizinones as orally available MEK inhibitors with potent in vivo antitumor efficacy. Synthesis and anti-HSV activity of methylenedioxy mappicine ketone analogs against herpes viruses.
Synthesis
616-45-5
77-78-1
5264-35-7
General procedure for the synthesis of 2-methoxy-1-pyrrolidine from 2-pyrrolidone and dimethyl sulfate: 23 mL (1 equiv.) of dimethyl sulfate was added slowly and dropwise to a solution of 20.03 g (0.235 mol) of 2-pyrrolidone dissolved in 85 mL of benzene, after which the reaction mixture was heated to 70 °C and kept at reflux for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and then 19 mL of 15 N sodium hydroxide solution was added. The reaction mixture was transferred to a partition funnel and the aqueous phase was extracted three times with benzene. The organic phases were combined and dried over anhydrous sodium sulfate, followed by evaporation of the solvent under reduced pressure. The residue was purified by vacuum distillation to afford 2-methoxy-1-pyrrolidine as a colorless liquid in 58% yield. The boiling point of the product was 37 °C (10^-2 mbar).1H NMR (CDCl3, 100 MHz) data were as follows: δ 1.97 (m, 2H), 2.41 (t, 2H), 3.61 (t, 2H), 3.75 (s, 3H).
References
[1] Arkivoc, 2016, vol. 2016, # 5, p. 118 - 141
[2] Journal of Organic Chemistry, 1995, vol. 60, # 9, p. 2912 - 2915
[3] Organic Preparations and Procedures International, 1992, vol. 24, # 2, p. 147 - 158
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 10, p. 1588 - 1593
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 25, p. 6307 - 6315
5-METHOXY-3,4-DIHYDRO-2H-PYRROLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXY-3,4-DIHYDRO-2H-PYRROLE manufacturers
- Product
- 5-methoxy-3,4-dihydro-2h-pyrrole 5264-35-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10