4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
- Product Name
- 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
- CAS No.
- 16694-17-0
- Chemical Name
- 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
- Synonyms
- Einecs 240-739-8;4-bromo-3-thenoic acid;4-Bromo-3-carboxythiophene;4-Bromothiophenecarboxylicacid;4-Bromo-3-thiophenecarboxylicacid;4-Bromothiophene-3-carvoxylic acid;4-BROMOTHIOPHENE-3-CARBOXYLIC ACID;3-Bromo-4-thiophenecarboxylic acid;3-Thiophenecarboxylic acid, 4-broMo-;4-Bromo-3-thiophenecarboxylic acid 97%
- CBNumber
- CB7704949
- Molecular Formula
- C5H3BrO2S
- Formula Weight
- 207.05
- MOL File
- 16694-17-0.mol
4-BROMOTHIOPHENE-3-CARBOXYLIC ACID Property
- Melting point:
- 157-159℃
- Boiling point:
- 318.0±27.0 °C(Predicted)
- Density
- 1.923±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.63±0.20(Predicted)
- color
- Off-white/faint brown
- InChI
- InChI=1S/C5H3BrO2S/c6-4-2-9-1-3(4)5(7)8/h1-2H,(H,7,8)
- InChIKey
- APBIZVFQQBCAAT-UHFFFAOYSA-N
- SMILES
- C1SC=C(Br)C=1C(O)=O
Safety
- Hazard Codes
- Xi
- WGK Germany
- 2
- Hazard Note
- Irritant
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 732214
- Product name
- 4-Bromo-3-thiophenecarboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $94.05
- Updated
- 2025/07/31
- Product number
- B678320
- Product name
- 4-Bromothiophene-3-carboxylicAcid
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB12074
- Product name
- 4-Bromothiophene-3-carboxylic acid
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR8605
- Product name
- 4-Bromothiophene-3-carboxylicacid
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- FB12074
- Product name
- 4-Bromothiophene-3-carboxylic acid
- Packaging
- 2g
- Price
- $232
- Updated
- 2021/12/16
4-BROMOTHIOPHENE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
3141-26-2
124-38-9
16694-17-0
Cool 100 mL of ether to -78°C under a nitrogen atmosphere. A 1.6 M n-butyllithium solution (28.4 mL) was slowly added. Subsequently, a solution of 3,4-dibromothiophene (10 g, 41.3 mmol) dissolved in 50 mL of ether was added dropwise over 10 min. The reaction temperature was maintained at -78 °C and stirring was continued for 10 min before an excess (>50 g) of fresh powdered dry ice (CO?) was added. The reaction mixture was stirred at -78°C for 1 hour, then 30 mL of 1 M NaOH solution (pre-diluted with 100 mL of water) was slowly added (note: CO? will be released). Gradually increase the temperature until the ice melts. Separate the organic and aqueous phases and extract the ether phase with 25 mL of 1 N NaOH solution. Combine all aqueous phases and acidify with 100 mL of 1 N HCl solution to pH < 7. Collect the precipitated white precipitate by filtration, wash with water, and dry in a vacuum oven to give 4-bromothiophene-3-carboxylic acid as a white solid (5.8 g, 68% yield).
References
[1] Pharmazie, 2006, vol. 61, # 11, p. 901 - 907
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994, # 19, p. 2735 - 2744
[3] Patent: WO2006/3096, 2006, A1. Location in patent: Page/Page column 71-72
[4] Patent: US2013/116233, 2013, A1. Location in patent: Paragraph 1018; 1019
[5] Patent: WO2014/140086, 2014, A1. Location in patent: Page/Page column 68-69
4-BROMOTHIOPHENE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID manufacturers
- Product
- 4-Bromothiophene-3-carboxylic acid 16694-17-0
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID 16694-17-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19