H-SER-LEU-ILE-GLY-LYS-VAL-NH2

ChemicalBook > CAS DataBase List > H-SER-LEU-ILE-GLY-LYS-VAL-NH2

H-SER-LEU-ILE-GLY-LYS-VAL-NH2

Product Name: H-SER-LEU-ILE-GLY-LYS-VAL-NH2
CAS No.: 190383-13-2
Chemical Name: H-SER-LEU-ILE-GLY-LYS-VAL-NH2
Synonyms: SLIGKV-NH2;Par-2 Ago;SLIGKVAMIDE;PAR-2 amide (1-6);PAR-2 AGONIST AMIDE;PAR-2 Agonist, amid;SLIGKV-NH2 TFA salt;PAR2 activating peptide;PAR-2 (1-6) AMIDE (HUMAN);SER-LEU-ILE-GLY-LYS-VAL-NH2
CBNumber: CB7715297
Molecular Formula: C28H54N8O7
Formula Weight: 614.78
MOL File: 190383-13-2.mol

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H-SER-LEU-ILE-GLY-LYS-VAL-NH2 Property

Boiling point:: 1030.3±65.0 °C(Predicted)
Density: 1.161±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: ≥13.48 mg/mL in EtOH with gentle warming and ultrasonic; ≥62.9 mg/mL in DMSO; ≥66.2 mg/mL in H2O
form: solid
pka: 12.04±0.10(Predicted)
Water Solubility: Soluble to 1 mg/ml in water
Sequence: H-Ser-Leu-Ile-Gly-Lys-Val-NH2

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S9192
Product name: Ser-Leu-Ile-Gly-Lys-Val-amide
Purity: ≥95% (HPLC), solid
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Tocris

Product number: 3010
Product name: SLIGKV-NH2
Packaging: 5
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 256692
Product name: SLIGKV-NH2
Packaging: 5mg
Price: $403
Updated: 2021/12/16

TRC

Product number: S560020
Product name: SLIGKV-NH2
Packaging: 5mg
Price: $145
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb372666
Product name: PAR-2 Agonist amide
Purity: > 95%
Packaging: 5mg
Price: $552.5
Updated: 2021/12/16

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H-SER-LEU-ILE-GLY-LYS-VAL-NH2 Chemical Properties,Usage,Production

Uses

SLIGKV-NH2 is a PAR2 agonist.

Definition

ChEBI: Ser-Leu-Ile-Gly-Lys-Val-Amide is an oligopeptide.

Biological Activity

sligkv-nh2 serves as a protease-activated receptor 2 (par2) agonist. pars are a group of g-protein-coupled receptors existing in several cell types. up to date, four par members including par1 to 4 have been identified, cloned and designated. par2 is expressed in the respiratory and gastrointestinal tracts. it is suggested that the activation of par2 is closely correlated with inflammatory evens in various cells and tissues. par2 has also been identified to induce protease activation and therefore result in systemic hypotension. [1]

Biochem/physiol Actions

Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus. PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.

in vitro

it was reported that sligkv-nh2 (the par2 activating peptide), by inducing express of par2, could slightly enhanced mucin secretion by human bronchial epithelial cells in vitro. according to this study, compared to cells treated with a control peptide with reversed amino acid sequence, exposure of cells to sligkv-nh2 for 30 mins resulted in a weak but statistically significant increase in mucin secretion at concentrations of 100 and 1000m. in addition, sligkv-nh2 was demonstrated to accelerate cell cycle progression and stimulate the growth of hepg2 cells. [1, 2]

in vivo

the ability of par2 agonists to induce contractile responses was investigated in vivo. it was found that mouse par2 activating (sligrl-nh2) and human par2 activating (sligkv-nh2) peptides triggered a concentration-dependent contractile response in guinea-pig gallbladder. [3]

IC 50

a protease-activated receptor 2 (par2) agonist with an ic50 of 10.4 m.

storage

Store at -20°C

References

[1] lin kw, park j, crews al, li yh, adler kb. protease-activated receptor-2 (par-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro. int j biochem cell b. 2008. 40: 137988.
[2]xie l, zheng y, li x, zhao jy, chen xy, chen l, zhou j, hai o and li f. enhanced proliferation of human hepatoma cells by par-2 agonists via the erk/ap-1 pathway. oncol rep. 2012.28: 1665-72.
[3] tognetto m, trevisani m, maggiore b, navarra g, turini a, guerrini r, bunnett nw, geppetti p and harrison s. evidence that par-1 and par-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder. br.j.pharmacol. 2000.131: 689-94.
[4] robin j, kharbanda r, mclean p, campbell r, vallance p. protease-activated receptor 2–mediated vasodilatation in humans in vivo, role of nitric oxide and prostanoids. circulation. 2003;107:954-959.

H-SER-LEU-ILE-GLY-LYS-VAL-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H-SER-LEU-ILE-GLY-LYS-VAL-NH2 manufacturers

Career Henan Chemical Co

Product: H-SER-LEU-ILE-GLY-LYS-VAL-NH2 190383-13-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

190383-13-2, H-SER-LEU-ILE-GLY-LYS-VAL-NH2Related Search:

H-SER-LEU-ILE-GLY-LYS-VAL-NH2

PROTEASE-ACTIVATED RECEPTOR-2 AGONIST, AMIDE

PROTEINASE ACTIVATED RECEPTOR 2 (1-6) AMIDE (HUMAN)

PROTEINASE ACTIVATED RECEPTOR 2 AGONIST PEPTIDE SLIGKV AMIDE, HUMAN

SER-LEU-ILE-GLY-LYS-VAL-AMIDE

SER-LEU-ILE-GLY-LYS-VAL-NH2

SLIGKVAMIDE

SLIGKV-NH2

PAR-2 AGONIST PEPTIDE (SLIGKV) AMIDE, HUMAN

PAR-2 (1-6) AMIDE (HUMAN)

PAR-2 AGONIST AMIDE

THROMBIN RECEPTOR-LIKE 1 (1-6) AMIDE (HUMAN)

COAGULATION FACTOR II RECEPTOR-LIKE 1 (1-6) AMIDE (HUMAN)

H-SER-LEU-ILE-GLY-LYS-VAL-NH2

Par-2 Ago

Protease - Activated Receptor - 2, PAR - 2 Agonist, amide

ThroMbin Receptor-Like 1 (1-6) aMide (huMan), SLIGKVaMide, Proteinase Activated Receptor 2 (1-6) aMide (huMan), Coagulation Factor II Receptor-Like 1 (1-6) aMide (huMan)

PAR2 activating peptide

Protease-Activated Receptor-2, amide (SLIGKV-NH2)

L-Valinamide, L-seryl-L-leucyl-L-isoleucylglycyl-L-lysyl-

Ser-Leu-Ile-Gly-Lys-Val-amide >=95% (HPLC), solid

Protease-activated receptor 2 (PAR2) agonist(SLIGKV-NH2)

H-SER-LEU-ILE-GLY-LYS-VAL-NH2 USP/EP/BP

ProteaseActivated Receptor2, amide,Protease Activated Receptor (PAR),Inhibitor,Thrombin receptors,inhibit,Protease Activated Receptor 2, amide

L-Seryl-L-leucyl-L-isoleucylglycyl-L-lysyl-L-valinamide

PAR-2 Agonist, amid

PAR-2 amide (1-6)

SLIGKV-NH2 TFA salt

190383-13-2

C28H54N8O7

Immune Cell Signaling and Blood

Immune System Regulation

Immunomodulators and Antibiotics

Cell Biology

Cell Signaling and Neuroscience

BioChemical

peptide

Immune Cell Signaling and Blood

Immune System Regulation

Immunomodulators and Antibiotics