ChemicalBook > CAS DataBase List > 4,6-DIMETHYL-2-NITROANILINE

4,6-DIMETHYL-2-NITROANILINE

Product Name
4,6-DIMETHYL-2-NITROANILINE
CAS No.
1635-84-3
Chemical Name
4,6-DIMETHYL-2-NITROANILINE
Synonyms
6-nitro-2,4-xylidine;4,6-DIMETHYL-2-NITROANILINE;2,4-Dimethyl-6-nitroBenzenamine;2,4-Dimethyl-6-nitroaniline 97%;2,4-Dimethyl-6-nitroaniline, 97%;4,6-Dimethyl-2-nitroaniline, 97%,;Benzenamine, 2,4-dimethyl-6-nitro-;5-NITRO-4-AMINO-1,3-DIMETHYLBENZENE;1-(2-methylpropyl)pyrrolidine-2,5-dione;4,6-DIMETHYL-2-NITROANILINE, TECH., 90%
CBNumber
CB7718526
Molecular Formula
C8H10N2O2
Formula Weight
166.18
MOL File
1635-84-3.mol
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4,6-DIMETHYL-2-NITROANILINE Property

Melting point:
64-68 °C(lit.)
Boiling point:
319.1±37.0 °C(Predicted)
Density 
1.220±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
pka
0.27±0.25(Predicted)
Appearance
Yellow to orange Solid
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39
RIDADR 
UN2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D465715
Product name
2,4-Dimethyl-6-nitroaniline
Packaging
10g
Price
$360
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD133701
Product name
(2,4-Dimethyl-6-nitrophenyl)amine
Packaging
500mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-W008334
Product name
2,4-Dimethyl-6-nitroaniline
Purity
99.78%
Packaging
5g
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-W008334
Product name
2,4-Dimethyl-6-nitroaniline
Purity
99.78%
Packaging
10g
Price
$97
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD133701
Product name
(2,4-Dimethyl-6-nitrophenyl)amine
Packaging
1g
Price
$105
Updated
2021/12/16
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4,6-DIMETHYL-2-NITROANILINE Chemical Properties,Usage,Production

Uses

2,4-Dimethyl-6-nitroaniline is used as a reagent in the synthetic preparation of 1,2-bis-substituted benzimidazoles as nonnucleoside HIV-1 reverse transcriptase inhibitors.

Synthesis

95-68-1

1635-84-3

General procedure for the synthesis of 2-nitro-4,6-dimethylaniline from 2,4-dimethylaniline: 2,4-dimethylaniline (8.0 g, 66.0 mmol) was dissolved in acetic anhydride (50 mL) and concentrated nitric acid (5 mL) was added slowly and dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 30 min and then diluted with ice water (200 mL). Subsequently, concentrated hydrochloric acid (10 mL) was added dropwise to the mixture and the resulting mixture was stirred under reflux conditions for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The residue was diluted with aqueous ammonium hydroxide and the resulting orange solid was filtered and dried to give 2-nitro-4,6-dimethylaniline (10.6 g, 97% yield).

References

[1] Patent: WO2009/25478, 2009, A1. Location in patent: Page/Page column 33; 52-53
[2] Patent: US2010/197673, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: KR101511771, 2015, B1. Location in patent: Paragraph 0406; 0407
[4] Tetrahedron Asymmetry, 2003, vol. 14, # 10, p. 1267 - 1273
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8743 - 8749

4,6-DIMETHYL-2-NITROANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,6-DIMETHYL-2-NITROANILINE manufacturers

Career Henan Chemical Co
Product
4,6-DIMETHYL-2-NITROANILINE 1635-84-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

1635-84-3, 4,6-DIMETHYL-2-NITROANILINERelated Search:

N,N-DIMETHYL-O-NITROANILINE,N,N-DIMETHYL-2-NITROANILINE 4,6-DIMETHYL-2-NITROANILINE Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate 4-Fluoro-N,N-dimethyl-2-nitroaniline N,2-DIMETHYL-4-NITROANILINE 4,5-DIMETHYL-2-NITROANILINE / 6-NITRO-3,4-XYLIDINE,4,5-DIMETHYL-2-NITROANILINE 4-AMINO-NN-DIMETHYL-3-NITROANILINE 97%,4-Amino-N,N-dimethyl-3-nitroaniline, GC 97%,4-AMINO-N,N-DIMETHYL-3-NITROANILINE 3-AMINO-N,N-DIMETHYL-4-NITROANILINE,3-AMINO-NN-DIMETHYL-4-NITROANILINE 97% 2-TRIFLUOROMETHYL-N,N-DIMETHYL-4-NITROANILINE N,N-DIMETHYL-3-NITROANILINE,N,N-DIMETHYL-M-NITROANILINE N,N-Dimethyl-4-nitroaniline, 98+%,N,N-DIMETHYL-P-NITROANILINE,N,N-DIMETHYL-4-NITROANILINE 2-CHLORO-N,N-DIMETHYL-4-NITROANILINE 2,3-DIMETHYL-6-NITROANILINE 98%,2,3-DIMETHYL-6-NITROANILINE 3-TRIFLUOROMETHYL-N,N-DIMETHYL-4-NITROANILINE 2,5-DIMETHYL-4-NITROANILINE 4-BROMO-2,3-DIMETHYL-6-NITROANILINE 1,5-DIMETHYL-2,3-DINITROBENZENE N-(2,4-dimethyl-6-nitro-phenyl)acetamide

  • 4,6-DIMETHYL-2-NITROANILINE, TECH., 90%
  • Benzenamine, 2,4-dimethyl-6-nitro-
  • 2,4-Dimethyl-6-nitroaniline 97%
  • 2,4-Dimethyl-6-nitroBenzenamine
  • 4,6-DIMETHYL-2-NITROANILINE
  • 5-NITRO-4-AMINO-1,3-DIMETHYLBENZENE
  • 6-nitro-2,4-xylidine
  • 1-(2-methylpropyl)pyrrolidine-2,5-dione
  • 4,6-DIMETHYL-2-NITROANILINE ISO 9001：2015 REACH
  • 4,6-Dimethyl-2-nitroaniline, 97%,
  • 2,4-Dimethyl-6-nitroaniline, 97%
  • 1635-84-3
  • Nitrogen Compounds
  • Organic Building Blocks
  • Building Blocks
  • Amines
  • C8
  • Building Blocks
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
  • Amines
  • C8
  • Nitrogen Compounds