GSK717

Product Name: GSK717
CAS No.: 1595278-21-9
Chemical Name: GSK717
Synonyms: GSK717;GSK717, 10 mM in DMSO;1H-Benzimidazole-1-acetamide, 2-[2-(benzoylmethylamino)ethyl]-N-(2,3-dihydro-1H-inden-5-yl)-;N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)ao)-2-oxoethyl)-1H-benzo[D]imidazol-2-yl)ethyl)-N-methylbenzamide;N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide;immune,GSK717,inhibit,Inhibitor,NOD2-TLR2,pro-inflammatory,MDP-stimulated,NOD-like Receptor (NLR),responses,cytokines,synergy,GSK 717,GSK-717
CBNumber: CB77243681
Molecular Formula: C28H28N4O2
Formula Weight: 452.56
MOL File: 1595278-21-9.mol

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GSK717 Property

Boiling point:: 731.6±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 250 mg/mL (552.43 mM)
pka: 14.05±0.20(Predicted)
form: Solid
color: White to off-white

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.33718
Product name: NOD2 Signaling Inhibitor II, GSK717
Packaging: 10 mg
Price: $246
Updated: 2025/07/31

ChemScene

Product number: CS-0131154
Product name: GSK717
Purity: 99.83%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0131154
Product name: GSK717
Purity: 99.83%
Packaging: 100mg
Price: $900
Updated: 2021/12/16

ChemScene

Product number: CS-0131154
Product name: GSK717
Purity: 99.83%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0131154
Product name: GSK717
Purity: 99.83%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

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GSK717 Chemical Properties,Usage,Production

Uses

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1].

Biological Activity

Cell permeable: yes', 'Primary Target
NOD2', 'Reversible: yes', 'Target IC50: 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells

References

[1] Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1. DOI:10.1371/journal.pone.0069619

GSK717 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK717 Suppliers

China 26 United States 3 Global 29

SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD

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Changzhou Chenhong Biotechnology Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Abmole Bioscience Inc.

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Beijing Jin Ming Biotechnology Co., Ltd.

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1595278-21-9, GSK717Related Search:

GSK717

1H-Benzimidazole-1-acetamide, 2-[2-(benzoylmethylamino)ethyl]-N-(2,3-dihydro-1H-inden-5-yl)-

N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)amino)-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)-N-methylbenzamide

immune,GSK717,inhibit,Inhibitor,NOD2-TLR2,pro-inflammatory,MDP-stimulated,NOD-like Receptor (NLR),responses,cytokines,synergy,GSK 717,GSK-717

GSK717, 10 mM in DMSO

N-(2-(1-(2-((2,3-Dihydro-1H-inden-5-yl)ao)-2-oxoethyl)-1H-benzo[D]imidazol-2-yl)ethyl)-N-methylbenzamide

1595278-21-9