Methyl 2,3-diaminobenzoate
Application- Product Name
- Methyl 2,3-diaminobenzoate
- CAS No.
- 107582-20-7
- Chemical Name
- Methyl 2,3-diaminobenzoate
- Synonyms
- 2,3-DIAMINOBENZOIC ACID METHYL ESTER;METHYL 2,3-DIAMINOBENZOATE;Benzoic acid, 2,3-diamino-, methyl ester;2,3-Diaminobenzoic Acid Methyl Ester Discontinued. See D416211
- CBNumber
- CB7724743
- Molecular Formula
- C8H10N2O2
- Formula Weight
- 166.18
- MOL File
- 107582-20-7.mol
Methyl 2,3-diaminobenzoate Property
- Melting point:
- 68-70°C
- Boiling point:
- 322.6±22.0 °C(Predicted)
- Density
- 1.260±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- pka
- 3.02±0.10(Predicted)
- form
- powder to crystal
- color
- Light yellow to Brown
- InChI
- InChI=1S/C8H10N2O2/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4H,9-10H2,1H3
- InChIKey
- BLJHLOLVEXWHFS-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC(N)=C1N
- CAS DataBase Reference
- 107582-20-7(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37/39-36/37
- HS Code
- 2921599090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M2979
- Product name
- Methyl 2,3-Diaminobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $85
- Updated
- 2025/07/31
- Product number
- M2979
- Product name
- Methyl 2,3-Diaminobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $274
- Updated
- 2025/07/31
- Product number
- 075301
- Product name
- 2,3-Diaminobenzoic acid methyl ester
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 075301
- Product name
- 2,3-Diaminobenzoic acid methyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- FD11827
- Product name
- 2,3-Diaminobenzoic acid methyl ester
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
Methyl 2,3-diaminobenzoate Chemical Properties,Usage,Production
Application
2,3-Diaminobenzoate is a pharmaceutical intermediate that can be used to prepare methyl 2-ethoxy-4-carboxylate-3-hydro-benzimidazole, which in turn can be used to prepare triphenylmethylcandesartan intermediate.
Chemical Properties
Yellow Solid
Anticancer Research
2,3-Diaminobenzoic acid methyl ester is a redox potential catalyst that has been shown to have anticancer activity in vitro and in vivo. It is a 5-ht4 receptor agonist, which causes an increase in the intracellular concentration of cAMP. The anticancer effect of this compound may be due to its ability to inhibit the growth of cancer cells by blocking DNA synthesis and cell division.
Synthesis
57113-91-4
107582-20-7
General procedure for the synthesis of methyl 2,3-diaminobenzoate from methyl 2-amino-3-nitrobenzoate: to a nitrogen-saturated solution of methyl 2-amino-3-nitrobenzoate (Chess GmbH, 50 g, 0.26 mol) in anhydrous ethanol (800 mL) was added palladium hydroxide (Degussa, 20% w/w carbon, 58.75% w/w water. 10g). The mixed slurry was degassed and stirred vigorously at room temperature under hydrogen (4 atm) atmosphere for 48 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to give methyl 2,3-diaminobenzoate as a dark orange oil, which solidified to a solid after standing (43 g, 0.26 mol, 100% yield). Mass spectrometry analysis (m/z): calculated value of [M-OCH3]+ C8H10N2O2 was 135.05; measured value was 135.3.1H NMR (300 MHz, DMSO-d6) data: δ (ppm) 3.74 (s, 3H), 4.80 (br s, 1H), 6.20 (br s, 1H), 6.38 (t, 1H). 6.70 (d, 1H), 7.06 (d, 1H).
References
[1] Patent: US2006/270652, 2006, A1. Location in patent: Page/Page column 14
[2] Patent: WO2010/3048, 2010, A1. Location in patent: Page/Page column 117
[3] Patent: WO2008/157270, 2008, A1. Location in patent: Page/Page column 126
[4] Patent: EP1452528, 2004, A1. Location in patent: Page 22
[5] Patent: US2009/186879, 2009, A1. Location in patent: Page/Page column 50
Methyl 2,3-diaminobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2,3-diaminobenzoate manufacturers
- Product
- Methyl 2,3-diaminobenzoate 107582-20-7
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-15
- Product
- Methyl 2,3-diaminobenzoate 107582-20-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06