HARMALOL HYDROCHLORIDE DIHYDRATE

Product Name: HARMALOL HYDROCHLORIDE DIHYDRATE
CAS No.: 6028-00-8
Chemical Name: HARMALOL HYDROCHLORIDE DIHYDRATE
Synonyms: HARMALOL HYDROCHLORID DIHYDRAT;ARMALOL HYDROCHLORIDE DIHYDRATE;HARMALOL HYDROCHLORIDE DIHYDRATE;HARMALOL HYDROCHLORIDE HYDRATE 98%;Harmalol hydrochloride hydrate,98%;Harmalol dihydrate hydrochloride;1-Methyl-4,9-dihydro-(3H)-beta-carbolin-7-olHCl;4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol;4,9-DIHYDRO-1-METHYL-3H-PYRIDO[3,4-B]INDOL-7-OL DIHYDRATE;1-METHYL-7-HYDROXY-3,4-DIHYDRO-BETA-CARBOLINE HYDROCHLORIDE DIHYDRATE
CBNumber: CB7730915
Molecular Formula: C12H12N2O.HCl.H2O
Formula Weight: 254.72
MOL File: 6028-00-8.mol

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HARMALOL HYDROCHLORIDE DIHYDRATE Property

Melting point:: 265-268 °C (dec.)
storage temp.: Refrigerator (+4°C)
solubility: DMF:10.0(Max Conc. mg/mL);36.67(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.67(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);7.33(Max Conc. mM)
form: A solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H125
Product name: Harmalol hydrochloride dihydrate
Purity: monoamine oxidase inhibitor
Packaging: 1g
Price: $256
Updated: 2022/05/15

TRC

Product number: H105153
Product name: Harmalol hydrochloride dihydrate
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 279981
Product name: Harmalol hydrochloride dihydrate
Packaging: 250mg
Price: $347
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH52360
Product name: Harmalol hydrochloride dihydrate
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FH52360
Product name: Harmalol hydrochloride dihydrate
Packaging: 500mg
Price: $125
Updated: 2021/12/16

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HARMALOL HYDROCHLORIDE DIHYDRATE Chemical Properties,Usage,Production

Description

Harmalol is a β-carboline alkaloid and an active metabolite of harmaline that has been found in P. harmala and has diverse biological activities.1,2,3,4,5 It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.63 µM) and monoamine oxidase A (MAO-A; IC50 = 0.66 µM).3 It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.4 It reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM.5 This product is also available as an analytical reference standard (Item No. 35145).WARNING This product is not for human or veterinary use.

Chemical Properties

yellow crystalline powder

HARMALOL HYDROCHLORIDE DIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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HARMALOL HYDROCHLORIDE DIHYDRATE Suppliers

Belgium 1 China 16 Europe 1 Germany 2 Japan 1 Switzerland 3 United Kingdom 6 United States 7 Global 37

J & K SCIENTIFIC LTD.

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Finetech Industry Limited

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6028-00-8, HARMALOL HYDROCHLORIDE DIHYDRATERelated Search:

HARMALOL harmaline hydrochloride HARMALINE HYDROCHLORIDE DIHYDRATE HARMALOL HYDROCHLORIDE DIHYDRATE

HARMALOL HYDROCHLORIDE DIHYDRATE

1-METHYL-7-HYDROXY-3,4-DIHYDRO-BETA-CARBOLINE HYDROCHLORIDE DIHYDRATE

HARMALOL HYDROCHLORID DIHYDRAT

HARMALOL HYDROCHLORIDE HYDRATE 98%

1-Methyl-4,9-dihydro-(3H)-beta-carbolin-7-olHCl

Harmalol dihydrate hydrochloride

Harmalol hydrochloride hydrate,98%

4,9-DIHYDRO-1-METHYL-3H-PYRIDO[3,4-B]INDOL-7-OL DIHYDRATE

4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol

ARMALOL HYDROCHLORIDE DIHYDRATE

6028-00-8

C12H12N2OHClH2O

C12H12N2OHCl2H2O

Heterocyclic Compounds

Alkaloid

Biochemicals Found in Plants

Nutrition Research