ChemicalBook > CAS DataBase List > 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE

2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE

Product Name
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE
CAS No.
511-13-7
Chemical Name
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE
Synonyms
ulo;sk74;ulone;sl501;refugal;coldrin;detigon;bayer-186;pectolitan;bayerb-186
CBNumber
CB7744592
Molecular Formula
C17H21Cl2NO
Formula Weight
326.26
MOL File
511-13-7.mol
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2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Property

Melting point:
190-191°
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
CAS DataBase Reference
511-13-7(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37/39-45
RIDADR 
3249
RTECS 
DC7600000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 orally in rats: 350 mg/kg; s.c. in mice: 95 mg/kg (Lorenz)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological
Product number
006963
Product name
Clofedanol Hydrochloride
Packaging
50mg
Price
$460
Updated
2021/12/16
TRC
Product number
C586920
Product name
ClofedanolHydrochloride
Packaging
2.5g
Price
$965
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20497
Product name
Clofedanol hydrochloride
Packaging
5mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20497
Product name
Clofedanol hydrochloride
Packaging
10mg
Price
$500
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
44700
Product name
ClofedanolHCl
Packaging
50mg
Price
$650
Updated
2021/12/16
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2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Abehol,Pliva

Uses

A centrally-acting cough suppressant. It has local anesthetic and antihistamine properties, and may have anticholinergic effects at high doses.

Definition

ChEBI: Chlophedianol hydrochloride is a diarylmethane.

Manufacturing Process

To a suspension of 330.0 g of sodamide (moistened with toluene) in 1500 ml of absolute ether, a solution of 1080.0 g of o-chlorobenzophenone and 350.0 g of acetonitrile in 3500 ml of absolute ether was gradually added dropwise, with stirring, such that the reaction temperature adjusted itself to 28°-30°C. The reaction mixture was stirred for 12 to 15 h at room temperature and was then added carefully to some ice water. The resulting solution was extracted 3 times with ether. The ether solution was washed with water, dried over Na2SO4, filtered, and finally concentrated. When 1 L of petroleum ether was added, 1240.0 g (96% of theoretical) of β-phenyl-β-o-chlorophenylhydroacrylonitrile (melting point 90°-92°C) precipitated.
500.0 g of the β-phenyl-β-o-chlorophenyl-hydroacrylonitrile were dissolved in 3 L of methanol and hydrogenated in the presence of 50.0 g of Raney cobalt at a temperature of 60°-70°C and a pressure of 80-85 ATM. Two moles of hydrogen were absorbed, and after separation of the methanolic solution from the catalyst, 450.0 g of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 of melting point 117°C were obtained.
Catalytic methylation of 1-o-chlorophenyl-1-phenyl-3-aminopropanol-1 (hydrogenation in the presence of 2.2 mol of formaldehyde in aqueous methanol with Raney nickel catalyst) yielded 450.0 g of l-o-chlorophenyl-1- phenyl-3 dimethylaminopropanol-1 of melting point 120°C.
In practice it is usually used as hydrochloride.

brand name

Ulo (3M Pharmaceuticals).

Therapeutic Function

Antitussive

2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

(2-Chlorophenyl)phenyl-methanone

Preparation Products

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2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE Suppliers

Canada 1 China 54 China Hong Kong 1 Europe 2 India 4 Italy 2 Switzerland 1 United Kingdom 3 United States 19 Global 87
TopScience Biochemical
Tel
00852-68527855
Fax
00852-26406298
Email
info@itopbiochem.com
Country
China Hong Kong
ProdList
902
Advantage
58
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View Lastest Price from 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE 511-13-7
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-07-14
Career Henan Chemical Co
Product
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE 511-13-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11
Career Henan Chemical Co
Product
2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE 511-13-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1
Release date
2018-08-06

511-13-7, 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDERelated Search:

Lincomycin hydrochloride Bromhexine hydrochloride Cetirizine dihydrochloride clofedanol 3-Dimethylamino-1-propanol Benzhydrol (2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE

  • 2-Chloro-[2-(dimethylamino)ethyl]-Phenyl-benzenemethanolhydrochloride
  • 2-chloro-alpha-(2-(dimethylamino)ethyl)-alpha-phenyl-benzenemethanohydro
  • 2-chloro-alpha-(2-(dimethylamino)ethyl)-benzhydrohydrochloride
  • 2-chloro-alpha-[2-(dimethylamino)ethyl]-alpha-phenyl-benzenemethanohydro
  • detigon-bayer
  • pectolitan
  • refugal
  • sk74
  • sl501
  • ulo
  • ulone
  • Clofedannol HCI
  • alpha-(2-dimethylaminoethyl)-o-chlorobenzhydrolhydrochloride
  • bayer-186
  • bayerb-186
  • chlorphedianol,hydrochloride
  • clofedanolhydrochloride
  • clophedianolhydrochloride
  • coldrin
  • detigon
  • 2-Chloro-α-[2-dimethylaminoethyl] benzhydrol hydrochloride
  • Benzenemethanol, 2-chloro-α-[2-(dimethylamino)ethyl]-α-phenyl-, hydrochloride
  • Benzhydrol, 2-chloro-α-[2-(dimethylamino)ethyl]-, hydrochloride (7CI, 8CI)
  • α-(2-Dimethylaminoethyl)-o-chlorobenzhydrol hydrochloride
  • 2-chloro-alpha-(2-(dimethylamino)ethyl)-alpha-phenyl-benzenemethano hydro chlophedianol hydrochloride
  • 2-chloro-alpha-(2-(dimethylamino)ethyl)-benzhydro hydrochloride 1-o-chlorophenyl-1-phenyl-3-dimethylamino-1-propanol hydrochloride
  • 2-chloro-alpha-(2-(dimethylamino)-ethyl)benzhydrol hydrochloride alpha-(2-dimethylaminoethyl)-o-chlorobenzhydrol
  • hydrochloride bayer b-186
  • CLOFEDANOL HCL
  • CHLOPHEDIANOL
  • CHLOPHEDIANOL HYDROCHLORIDE
  • 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE
  • 2-Chloro-α-[2-(diMethylaMino)ethyl]-α-phenylbenzeneMethanol
  • Hydrochloric acid chlophedianol
  • 1-o-chlorophenyl-1-phenyl-3-dimethylamino-1-propanolhydrochloride
  • 2-CHLORO-ALPHA-[2-DIMETHYLAMINOETHYL]BENZHYDROL HYDROCHLORIDE USP/EP/BP
  • Benzenemethanol,2-chloro-a-[2-(dimethylamino)ethyl]-a-phenyl-,hydrochloride (1:1)
  • Chlophedianol Hcl
  • 511-13-7
  • C17H20ClNOHCl
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals