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H-TRP-GLU-OH

Product Name
H-TRP-GLU-OH
CAS No.
36099-95-3
Chemical Name
H-TRP-GLU-OH
Synonyms
WE;G3335;TRP-GLU;L-TRP-GLU;H-TRP-GLU-OH;TRP-GLU CRYSTALLINE;PPARγ Antagonist III,G3335;L-TRYPTOPHYL-L-GLUTAMIC ACID;L-Glutamic acid, L-tryptophyl-;PPARγ Antagonist III, G3335 - CAS 36099-95-3 - Calbiochem
CBNumber
CB7745599
Molecular Formula
C16H19N3O5
Formula Weight
333.34
MOL File
36099-95-3.mol
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H-TRP-GLU-OH Property

Melting point:
>163°C(dec.)
Boiling point:
720.7±60.0 °C(Predicted)
Density 
1.428±0.06 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
White solid
pka
3.02±0.10(Predicted)
color 
white to off-white
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1449
Product name
G3335
Purity
≥98% (HPLC)
Packaging
50mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
516566
Product name
PPARγ Antagonist III, G3335
Packaging
50mg
Price
$159
Updated
2024/03/01
Alfa Aesar
Product number
J64528
Product name
G3335
Packaging
50mg
Price
$122
Updated
2023/06/20
Alfa Aesar
Product number
J64528
Product name
G3335
Packaging
100mg
Price
$208
Updated
2023/06/20
Cayman Chemical
Product number
17593
Product name
G3335
Purity
≥98%
Packaging
10mg
Price
$32
Updated
2024/03/01
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H-TRP-GLU-OH Chemical Properties,Usage,Production

Uses

A cell-permeable dipeptide that acts as a selective and reversible peroxisome proliferator-activated receptor antagonist

Definition

ChEBI: Trp-Glu is a dipeptide formed from L-tryptophan and L-glutamic acid residues. It has a role as a metabolite.

Biological Activity

kd = 8.34 μmg3335 is a pparγ antagonist.the peroxisome proliferator-activated receptor gamma (ppargamma) is a key therapeutic drug target for several conditions, such as inflammation, diabetes, hypertension, dyslipidemia, and cancer.

in vitro

biacore 3000 study based on the surface plasmon resonance technique found that g3335 exhibited a highly specific binding affinity against ppargamma and was able to block rosiglitazone, a potent ppargamma agonist, in the stimulation of the interaction between the ppargamma ligand-binding domain (lbd) and rxralpha-lbd. moreover, the yeast two-hybrid assays indicated that g3335 had strong antagonistic activity in perturbing rosiglitazone in the promotion of the ppargamma-lbd-cbp interaction. in addition, g3335 could competitively bind to ppargamma against 0.1 microm rosiglitazone to repress reporter-gene expression [1].

in vivo

in a previous study, the effect of rosiglitazone was examined on spinal cord injury (sci) in rats. the animals were randomly divided into vehicle group, rosiglitazone treated group, and g3335 treated group. locomotor function recovery was evaluated. results showed that compared with the vehicle groups, the rosiglitazone could significantly ameliorate locomotor recovery, reduce nf-κb expression, and increase the proliferation of endogenous npcs. in addition, when the ppar-γ antagonist g3335 was applied, such effects were abolished [2].

References

[1] ye, f. ,zhang, z.s.,luo, h.b., et al. the dipeptide h-trp-glu-oh shows highly antagonistic activity against pparγ: bioassay with molecular modeling simulation. chembiochem 7, 74-82 (2006).
[2] meng, q. q.,liang, x.j.,wang, p., et al. rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury. neuroscience letters 503, 191-195 (2011).

H-TRP-GLU-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-TRP-GLU-OH Suppliers

GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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86-21-61263399
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ymbetter@glbiochem.com
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China
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VDM Biochemicals
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0330-2528181
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0330-2528171
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sales@vdmbio.com
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
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051085625359
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sales@reading-chemicals.com
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Sichuan Ampebiochem Co., Ltd.
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028-65294243
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028-85275169
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sales@ampebiochem.com
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China
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BOC Sciences
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16314854226
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United States
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Chengdu Youngshe Chemical Co., Ltd.
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+86-17380623303 +86-17380623303
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028-62328193
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Caroline@youngshechem.com
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China
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36099-95-3, H-TRP-GLU-OHRelated Search:


  • TRP-GLU
  • H-TRP-GLU-OH
  • L-TRYPTOPHYL-L-GLUTAMIC ACID
  • L-TRP-GLU
  • TRP-GLU CRYSTALLINE
  • G3335
  • PPARγ Antagonist III,G3335
  • WE
  • PPARγ Antagonist III, G3335 - CAS 36099-95-3 - Calbiochem
  • L-Glutamic acid, L-tryptophyl-
  • 36099-95-3
  • A cell-permeable dipeptide that acts as a selective and reversible PPAR./ antagonist
  • Amino Acid Derivatives