ATROPINE METHYL NITRATE
- Product Name
- ATROPINE METHYL NITRATE
- CAS No.
- 52-88-0
- Chemical Name
- ATROPINE METHYL NITRATE
- Synonyms
- D01077;ekomine;europen;eumydrin;metanite;metropine;eumidrina;eumydrine;harvatrate;Ekomine (tn)
- CBNumber
- CB7747265
- Molecular Formula
- C18H26N2O6
- Formula Weight
- 366.41
- MOL File
- 52-88-0.mol
ATROPINE METHYL NITRATE Property
- Melting point:
- 163°C
- storage temp.
- -20°C
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- white
- Merck
- 875
- CAS DataBase Reference
- 52-88-0(CAS DataBase Reference)
- EPA Substance Registry System
- Methylatropine nitrate (52-88-0)
Safety
- Hazard Codes
- Xn,T+
- Risk Statements
- 22-26/28
- Safety Statements
- 22-36-45-25
- RIDADR
- 1544
- WGK Germany
- 3
- RTECS
- CK2800000
- Toxicity
- LD50 oral in rat: 1902mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- CHM0013737
- Product name
- ATROPINE METHYL NITRATE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $2555.27
- Updated
- 2021/12/16
- Product number
- A-7536
- Product name
- Atropinemethylnitrate(AMN)
- Packaging
- 50mg
- Price
- $1990
- Updated
- 2021/12/16
ATROPINE METHYL NITRATE Chemical Properties,Usage,Production
Chemical Properties
mp 162-164 C
Originator
Methylatropine,Paganfarma
Uses
Atropine methyl nitrate has been used to suppress mucus production and respiratory secretions in rats. It has also been used to study its effects on xanomeline-induced suppression of serum tumor necrosis factor.
Uses
antibacterial
Uses
cephalosporin antimicrobial
Manufacturing Process
There are 2 methods of synthesis of methyl atropine nitrate:
1) To a solution of 28.9 g atropine of in 100 g of methanol was added at
110°C for 2 hours 7.7 g methyl nitrate. Methanol was evaporated and methyl
atropine nitrate was crystallysed, M.P. 163°C.
2) To a solution of 70.4 g methyl atropine sulfate (prepared from methyl
atropine chloride and silver nitrate) in water was added aqueous solution of
26.1 g barium nitrate. Barium sulfate was deleted by filtration. Filtrate was
concentrated and the methyl atropine nitrate was obtained.
brand name
Ekomine (Hoechst-Roussel); Eumydrin (Sterling Winthrop).
Therapeutic Function
Anticholinergic, Mydriatic, Spasmolytic
Biochem/physiol Actions
Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (bladder, respiratory, to block parasympathetic signaling to the heart, etc.) and to separate central from peripheral effects or protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.
Safety Profile
Poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects: mydriasis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also ATROPINE and NITRATES.
ATROPINE METHYL NITRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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