1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHANONE Property

Melting point:

121 °C

Boiling point:

381.4±32.0 °C(Predicted)

Density 

1.247±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Acetone, Chloroform

form 

Solid

pka

8.13±0.18(Predicted)

color 

Off-White

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHANONE Chemical Properties,Usage,Production

Uses

1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-ethanone is an intermediate in synthesizing Albuterol Dimer Ether (A514520), which is an impurity of Albuterol (Salbutamol) (A514500). Albuterol impurity F. Albuterol is a β2-adrenoceptor agonist. Bronchodilator; tocolytic.

Preparation

Obtained by refluxing 3-chloromethyl-4-hydroxy-acetophenone with water for 3 h (70%).