AA-5-HT

Product Name: AA-5-HT
CAS No.: 187947-37-1
Chemical Name: AA-5-HT
Synonyms: AA-5-HT;ARACHIDONYLSEROTONIN;ARACHIDONOYL SEROTONIN;N-Arachidonoylserotonin;N-ARACHIDONYL-5-HYDROXYTRYPTAMINE;Arachidonoylserotonin >=98% (HPLC), oil;N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide;N-[2-(5-HYDROXY-1H-INDOL-3-YL)ETHYL]-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;(5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide;N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide
CBNumber: CB7754434
Molecular Formula: C30H42N2O2
Formula Weight: 462.67
MOL File: 187947-37-1.mol

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AA-5-HT Property

storage temp.: −20°C
solubility: DMSO: >10mg/mL
form: oil
color: yellow
Sensitive: Air & Light Sensitive

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7357
Product name: Arachidonoylserotonin
Purity: ≥98% (HPLC), oil
Packaging: 25mg
Price: $503
Updated: 2023/01/07

Cayman Chemical

Product number: 70665
Product name: Arachidonoyl Serotonin
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 70665
Product name: Arachidonoyl Serotonin
Purity: ≥98%
Packaging: 10mg
Price: $82
Updated: 2024/03/01

Cayman Chemical

Product number: 70665
Product name: Arachidonoyl Serotonin
Purity: ≥98%
Packaging: 100mg
Price: $570
Updated: 2024/03/01

Cayman Chemical

Product number: 70665
Product name: Arachidonoyl Serotonin
Purity: ≥98%
Packaging: 50mg
Price: $310
Updated: 2024/03/01

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AA-5-HT Chemical Properties,Usage,Production

Uses

N-Arachidonoylserotonin (Arachidonyl serotonin; AA-5-HT) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 value of 1~12 μM. N-Arachidonoylserotonin acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels (IC50=70~100 nM). N-Arachidonoylserotonin is analgesic in rodents [1].

Definition

ChEBI: N-arachidonoylserotonin is an N-acylserotonin obtained by formal condensation of the carboxy group of arachidonic acid with the primary amino group of serotonin. It has a role as a human metabolite, a signalling molecule, an antioxidant, an anti-inflammatory agent, an anticonvulsant, a capsaicin receptor antagonist and an EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor. It is a member of phenols and a N-acylserotonin. It is functionally related to an arachidonic acid.

Biological Activity

Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC 50 values are 5.6 μ M and 37-40 nM for FAAH and TRPV1 respectively). Inactive at cPLA 2 , CB 1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

References

[1] Ortar G, et al. New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem. 2007;50(26):6554-6569. DOI:10.1021/jm070678q

AA-5-HT Preparation Products And Raw materials

Raw materials

Preparation Products

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AA-5-HT Suppliers

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View Lastest Price from AA-5-HT manufacturers

Hebei Mingeng Biotechnology Co., Ltd

Product: Arachidonoyl serotonin 187947-37-1
Price: US $150.00/ASSAYS
Min. Order: 10g
Purity: >99%
Supply Ability: 500kg/month
Release date: 2021-12-24

187947-37-1, AA-5-HTRelated Search:

PSY-279 IBTU JYL-273 BCTC AA-5-HT

N-ARACHIDONYL-5-HYDROXYTRYPTAMINE

N-[2-(5-HYDROXY-1H-INDOL-3-YL)ETHYL]-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE

N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide

AA-5-HT, N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide

N-Arachidonoylserotonin

ARACHIDONYLSEROTONIN

ARACHIDONOYL SEROTONIN

AA-5-HT

N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenamide

(5Z,8Z,11Z,14Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]icosa-5,8,11,14-tetraenamide

5,8,11,14-Eicosatetraenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (5Z,8Z,11Z,14Z)-

Arachidonoylserotonin >=98% (HPLC), oil

187947-37-1

Vanilloid/TRPV channel