Z-D-MET-OH
- Product Name
- Z-D-MET-OH
- CAS No.
- 28862-80-8
- Chemical Name
- Z-D-MET-OH
- Synonyms
- Z-D-MET;Z-D-MET-OH;CBZ-D-MET-OH;N-Cbz-D-Met-OH;Z-D-METHIONINE;Cbz-D-Methinine;CBZ-D-METHIONINE;N-CBZ-D-METHIONINE;Z-D-MET-OH USP/EP/BP;Z-D-METHIONINE extrapure
- CBNumber
- CB7757394
- Molecular Formula
- C13H17NO4S
- Formula Weight
- 283.34
- MOL File
- 28862-80-8.mol
Z-D-MET-OH Property
- Melting point:
- 67-69°C
- Density
- 1.253
- refractive index
- 26 ° (C=1, MeOH)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
Safety
- Safety Statements
- 24/25
- HS Code
- 29225090
N-Bromosuccinimide Price
- Product number
- S777129
- Product name
- CARBOBENZYLOXY-D-METHIONINE
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- C0665
- Product name
- N-Carbobenzoxy-D-methionine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- C0665
- Product name
- N-Carbobenzoxy-D-methionine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $117
- Updated
- 2025/07/31
- Product number
- C0665
- Product name
- N-Carbobenzoxy-D-methionine
- Purity
- >98.0%(T)
- Packaging
- 100mg
- Price
- $16
- Updated
- 2025/07/31
- Product number
- C227740
- Product name
- N-Cbz-D-methionine
- Packaging
- 5g
- Price
- $110
- Updated
- 2021/12/16
Z-D-MET-OH Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
N-Cbz-D-methionine is an N-Cbz-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).
Synthesis
348-67-4
501-53-1
1152-62-1
General procedure for the synthesis of Z-L-methionine from D-methionine and benzyl chloroformate: (2R)-2-Amino-4-(methylthioalkyl)butyric acid (4.90 g, 32.84 mmol) and sodium carbonate (16.91 g, 159.54 mmol) were dissolved in water (100 mL) at room temperature. Subsequently, a solution of benzyl chloroformate (5.59 g, 32.74 mmol) in dioxane (50 mL) was added slowly and dropwise over 10 minutes. The resulting reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (100 mL). The reaction mixture was extracted with ethyl acetate (300 mL x 3) and the organic phases were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by chromatography on a C18 reversed-phase column using gradient elution with aqueous acetonitrile (0 to 50% acetonitrile, 30 min) to afford (2R)-2-[[(benzyloxy)carbonyl]amino]-4-(methylsulfanyl)butanoic acid as a yellow oil (3.48 g, 36% yield).
References
[1] Journal of Agricultural and Food Chemistry, 1995, vol. 43, # 10, p. 2728 - 2734
[2] Canadian Journal of Chemistry, 2003, vol. 81, # 8, p. 937 - 960
[3] Patent: WO2017/106607, 2017, A1. Location in patent: Paragraph 00400
Z-D-MET-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Z-D-MET-OH Suppliers
- Tel
- --
- Fax
- --
- swiss@sennchem.com
- Country
- Switzerland
- ProdList
- 3143
- Advantage
- 71
View Lastest Price from Z-D-MET-OH manufacturers
- Product
- Cbz-D-Met-OH 28862-80-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-15
- Product
- Z-D-MET-OH 28862-80-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-22