(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID
- Product Name
- (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID
- CAS No.
- 150436-68-3
- Chemical Name
- (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID
- Synonyms
- PMP;Envision;Lactisole;AKOS BBB/242;Lactisole sodium;Lactisole, 10 mM in DMSO;2-(4-methoxyphenoxy)propanoate;2-(4-METHOXYPHENOXY)PROPANOIC ACID;(2-(4-METHOXYPHENOXY))PROPIONIC ACID;Sodium2-(4-methoxyphenoxy)propanoicacid
- CBNumber
- CB7765904
- Molecular Formula
- C10H13NaO4
- Formula Weight
- 220.2
- MOL File
- 150436-68-3.mol
(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- White to off-white
- Odor
- at 100.00?%. bland
- InChI
- InChI=1S/C10H12O4.Na.H/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9;;/h3-7H,1-2H3,(H,11,12);;
- InChIKey
- WACRGINJFSUXIL-UHFFFAOYSA-N
- SMILES
- O(C1C=CC(OC)=CC=1)C(C)C(=O)O.[NaH]
- LogP
- 1.654 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 18657
- Product name
- Lactisole
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 18657
- Product name
- Lactisole
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 18657
- Product name
- Lactisole
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 18657
- Product name
- Lactisole
- Purity
- ≥98%
- Packaging
- 50g
- Price
- $477
- Updated
- 2024/03/01
- Product number
- S080855
- Product name
- Sodium2-(4-Methoxyphenoxy)propionate
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID Chemical Properties,Usage,Production
Description
Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence. It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds. Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.
Uses
Sodium 2-(4-methoxyphenoxy)propanoic acid is a taste modulator that inhibits the perception of sweetness in humans, but not in rats.
References
[1] C JOHNSON D B M G G Birch. The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli.[J]. Chemical Senses, 1994, 19 4: 349-358. DOI: 10.1093/chemse/19.4.349
[2] S S SCHIFFMAN. Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid.[J]. Chemical Senses, 1999, 24 4: 439-447. DOI: 10.1093/chemse/24.4.439
[3] KUNIHISA HAMANO. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells.[J]. Journal of Endocrinology, 2015, 226 1: 57-66. DOI: 10.1530/joe-15-0102
[4] JAEWON SHIM. Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2.[J]. PLoS ONE, 2015: e0124030. DOI: 10.1371/journal.pone.0124030
[5] YOSHIAKI OHTSU . Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells[J]. Molecular and Cellular Endocrinology, 2014, 394 1: Pages 70-79. DOI: 10.1016/j.mce.2014.07.004
[6] SHINGO SATO. Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2013, 304 8: G708-14. DOI: 10.1152/ajpgi.00282.2012
(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID manufacturers
- Product
- (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID 150436-68-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-28
- Product
- Lactisole 150436-68-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-08-10
- Product
- (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID 150436-68-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-09-18