(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID

Product Name: (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID
CAS No.: 150436-68-3
Chemical Name: (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID
Synonyms: PMP;Envision;Lactisole;AKOS BBB/242;Lactisole sodium;Lactisole, 10 mM in DMSO;2-(4-methoxyphenoxy)propanoate;2-(4-METHOXYPHENOXY)PROPANOIC ACID;(2-(4-METHOXYPHENOXY))PROPIONIC ACID;Sodium2-(4-methoxyphenoxy)propanoicacid
CBNumber: CB7765904
Molecular Formula: C10H13NaO4
Formula Weight: 220.2
MOL File: 150436-68-3.mol

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(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to off-white
Odor: at 100.00?%. bland
InChI: InChI=1S/C10H12O4.Na.H/c1-7(10(11)12)14-9-5-3-8(13-2)4-6-9;;/h3-7H,1-2H3,(H,11,12);;
InChIKey: WACRGINJFSUXIL-UHFFFAOYSA-N
SMILES: O(C1C=CC(OC)=CC=1)C(C)C(=O)O.[NaH]
LogP: 1.654 (est)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18657
Product name: Lactisole
Purity: ≥98%
Packaging: 5g
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 18657
Product name: Lactisole
Purity: ≥98%
Packaging: 10g
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 18657
Product name: Lactisole
Purity: ≥98%
Packaging: 25g
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 18657
Product name: Lactisole
Purity: ≥98%
Packaging: 50g
Price: $477
Updated: 2024/03/01

TRC

Product number: S080855
Product name: Sodium2-(4-Methoxyphenoxy)propionate
Packaging: 1g
Price: $45
Updated: 2021/12/16

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(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID Chemical Properties,Usage,Production

Description

Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence. It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds. Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic β-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells.

Uses

Sodium 2-(4-methoxyphenoxy)propanoic acid is a taste modulator that inhibits the perception of sweetness in humans, but not in rats.

References

[1] C JOHNSON D B M G G Birch. The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli.[J]. Chemical Senses, 1994, 19 4: 349-358. DOI: 10.1093/chemse/19.4.349
[2] S S SCHIFFMAN. Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid.[J]. Chemical Senses, 1999, 24 4: 439-447. DOI: 10.1093/chemse/24.4.439
[3] KUNIHISA HAMANO. Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic β-cells.[J]. Journal of Endocrinology, 2015, 226 1: 57-66. DOI: 10.1530/joe-15-0102
[4] JAEWON SHIM. Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2.[J]. PLoS ONE, 2015: e0124030. DOI: 10.1371/journal.pone.0124030
[5] YOSHIAKI OHTSU . Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells[J]. Molecular and Cellular Endocrinology, 2014, 394 1: Pages 70-79. DOI: 10.1016/j.mce.2014.07.004
[6] SHINGO SATO. Dietary lipids and sweeteners regulate glucagon-like peptide-2 secretion.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2013, 304 8: G708-14. DOI: 10.1152/ajpgi.00282.2012

(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID Preparation Products And Raw materials

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(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID Suppliers

China 91 Germany 1 Russia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 5 United States 16 Global 118

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View Lastest Price from (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID 150436-68-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

Hebei Yanxi Chemical Co., Ltd.

Product: Lactisole 150436-68-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-08-10

Career Henan Chemical Co

Product: (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID 150436-68-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-09-18

150436-68-3, (+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACIDRelated Search:

2-Hydroxy-3-(2-methoxyphenoxy)propanoic acid 2-(4-METHOXYPHENOXY)PROPIONIC ACID SODIUM SALT 3-(4-allyl-2-methoxyphenoxy)propanoic acid 2-(3-METHOXYPHENOXY)PROPANOIC ACID 2-(4-FORMYL-2-METHOXYPHENOXY)PROPANOIC ACID 2-(2-CHLORO-4-FORMYL-6-METHOXYPHENOXY)PROPANOIC ACID 3-(p-Methoxyphenoxy)propionic acid,3-(p-Methoxyphenoxy)propanoic acid,3-(4-METHOXYPHENOXY)PROPANOIC ACID 3-(3-METHOXYPHENOXY)PROPIONIC ACID 2-(4-CHLORO-2-FORMYL-6-METHOXYPHENOXY)PROPANOIC ACID 3-(3-methoxyphenoxy)propanoic acid 2-(2-methoxyphenoxy)propanoic acid 2-(2-FORMYL-6-METHOXYPHENOXY)PROPANOIC ACID [R,(+)]-2-(p-Methoxyphenoxy)propionic acid 2-(3-Methoxyphenoxy)propanoic acid methyl ester 2-[4-({2-[(4-fluorophenyl)imino]-3-methyl-4-oxo-1,3-thiazolidin-5-ylidene}methyl)-2-methoxyphenoxy]propanoic acid 2-{4-[(7,8-dimethyl-3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]-2-methoxyphenoxy}propanoic acid 3-(2-tert-butyl-4-methoxyphenoxy)propanoic acid 3-(4-cyano-2-methoxyphenoxy)propanoic acid

PMP

AKOS BBB/242

2-(4-METHOXYPHENOXY)PROPANOIC ACID

(2-(4-METHOXYPHENOXY))PROPIONIC ACID

(+/-)-2-(P-METHOXYPHENOXY)PROPIONIC ACID

Envision

Lactisole

Propanoic acid, 2-(4-Methoxyphenoxy)-, sodiuM salt

Propanoic acid,2-(4-methoxyphenoxy)-, sodium salt (1:1)

2-(4-methoxyphenoxy)propanoate

Sodium2-(4-methoxyphenoxy)propanoicacid

2-(4-methoxyphenoxy)propanoic acid, sodium salt

Lactisole, 10 mM in DMSO

Lactisole sodium

150436-68-3

C10H11O4Na

Biochemicals and Reagents

BioChemical

Substrate Analogs

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Type